Maternal plasma prolidase, matrix metalloproteinases 1 and 13, and oxidative stress levels in pregnancies complicated by preterm premature rupture of the membranes and chorioamnionitis

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dc.contributor.authorSoydinc, Hatice Ender
dc.contributor.authorSak, Muhammet Erdal
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorEvsen, Mehmet Siddi
dc.contributor.authorTurgut, Abdulkadir
dc.contributor.authorOzler, Ali
dc.contributor.authorTay, Hayrettin
dc.date.accessioned2024-04-24T17:27:29Z
dc.date.available2024-04-24T17:27:29Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: This study aimed to investigate the role of various biochemical markers in preterm premature rupture of membranes (PPROM) and in prediction of chorioamnionitis in patients with PPROM. Material and Methods: This case-control study included a total of 100 pregnant women at 26-34 gestational weeks. Of these women, 50 were healthy and 50 had PPROM. The biochemical markers in the maternal plasma including prolidase, matrix metalloproteinase (MMP) 1 and 13, total oxidative status (TOS), total antioxidant capacity (TAC), glutathione peroxidase (GPx), catalase (CAT), paraoxonase-1 (PON-1), tumor necrosis factor alpha (TNF-alpha), and high sensitive C-reactive protein (hsCRP) were assayed. These levels were compared between the PPROM and control groups and between women with or without chorioamnionitis in the PPROM group. Results: Compared to the control group, the levels of prolidase, MMP13, and TOS were significantly higher (p values < 0.001, 0.020, and 0.035, respectively) and those of TAC and PON-1 were significantly lower in the maternal plasma of the PPROM group (p values= 0.012 and < 0.001, respectively). The plasma prolidase and TOS levels were significantly higher (p values= 0.033 and 0.005, respectively) and the plasma TAC and PON-1 levels were significantly lower in women with chorioamnionitis as compared with the corresponding values in women without chorioamnionitis in the PPROM group (p values = 0.041 and 0.048, respectively). The multivariate logistic regression analysis observed that prolidase, TAC, and PON-1 were important markers for the presence of PPROM and prolidase and TOS were important markers for predicting chorioamnionitis. Conclusion: This study suggested that maternal plasma prolidase, TAC, and PON-1 may be useful for the diagnosis of PPROM, and prolidase and TOS may be used to predict chorioamnionitis in patients with PPROM.en_US
dc.description.sponsorshipScientific Research and Project Coordinator (DUBAB) in Dicle University [10-TF-57]en_US
dc.description.sponsorshipThis study was supported by Scientific Research and Project Coordinator (DUBAB, 10-TF-57) in Dicle University.en_US
dc.identifier.doi10.5152/jtgga.2012.23
dc.identifier.endpage177en_US
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.issue3en_US
dc.identifier.pmid24592033en_US
dc.identifier.scopus2-s2.0-84866001716en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage172en_US
dc.identifier.trdizinid158705en_US
dc.identifier.urihttps://doi.org/10.5152/jtgga.2012.23
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/158705
dc.identifier.urihttps://hdl.handle.net/11468/19979
dc.identifier.volume13en_US
dc.identifier.wosWOS:000420652800006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofJournal of The Turkish-German Gynecological Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPreterm Premature Rupture Of Membranesen_US
dc.subjectMaternal Plasmaen_US
dc.subjectProlidaseen_US
dc.subjectMatrix Metalloproteinaseen_US
dc.subjectOxidative Stressen_US
dc.titleMaternal plasma prolidase, matrix metalloproteinases 1 and 13, and oxidative stress levels in pregnancies complicated by preterm premature rupture of the membranes and chorioamnionitisen_US
dc.typeArticleen_US

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