Protective effect of intravesical platelet-rich plasma on cyclophosphamide-induced hemorrhagic cystitis

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dc.contributor.authorÖzyuvalı, Ekrem
dc.contributor.authorYıldırım, Mehmet Erol
dc.contributor.authorYaman, Turan
dc.contributor.authorKösem, Bahadır
dc.contributor.authorAtlı, O.
dc.contributor.authorÇimentepe, Ersin
dc.date.accessioned2024-04-24T17:37:51Z
dc.date.available2024-04-24T17:37:51Z
dc.date.issued2016
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümü, Patoloji Ana Bilim Dalıen_US
dc.description.abstractPurpose: Hemorrhagic cystitis (HC) is the most common urotoxic side effect of cyclophosphamide (CYP). Platelet rich plasma (PRP) plays an important role in wound healing and inflammatory responses. The aim of this study was to investigate the efficacy of intravesical PRP at treatment of interstitial cystitis (IC). Material-Methods: Female rats (n=24) were used. IC was induced by intraperitoneal injection of cyclophosphamide (CYP). Rats were randomly allocated to one of four groups (n = 6 per group): a control group; a sham group with saline (75 mg/kg; i.p.) instead of CYP on day 1; a IC group, which was injected with CYP (150 mg/kg; i.p.) on day 1; and, a intravesical PRP-treated group which was injected with CYP (150 mg/kg; i.p.) on day 1. On day 2, the rats in each group were sacrificed under anesthesia. Results: Histological evaluation showed that bladder inflammation in CYP-treated rats was not suppressed by PRP. CYP administration induced severe IC with marked edema, hemorrhage and inflammation in CYP and CYP+PRP groups, but PRP was not found to be effective to decrease these effects. Conclusion: The application of PRP could not reverse the histopathological changes in rats that had interstitial cystitis due to the cyclophosphamide injection.en_US
dc.identifier.citationÖzyuvalı, E., Yıldırım, M. E., Yaman, T., Kösem, B., Atlı, O. ve Çimentepe, E. (2016). Protective effect of intravesical platelet-rich plasma on cyclophosphamide-induced hemorrhagic cystitis. Clinical and Investigative Medicine, 39(6), 116-120.
dc.identifier.endpageS120en_US
dc.identifier.issn0147-958X
dc.identifier.issn1488-2353
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85047593396
dc.identifier.scopusqualityQ2
dc.identifier.startpageS116en_US
dc.identifier.urihttps://hdl.handle.net/11468/21218
dc.identifier.volume39en_US
dc.identifier.wosWOS:000389725000024
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYaman, Turan
dc.institutionauthorAtlı, O.
dc.language.isoenen_US
dc.publisherCanadian Soc Clinical Investigationen_US
dc.relation.ispartofClinical and Investigative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleProtective effect of intravesical platelet-rich plasma on cyclophosphamide-induced hemorrhagic cystitisen_US
dc.titleProtective effect of intravesical platelet-rich plasma on cyclophosphamide-induced hemorrhagic cystitis
dc.typeArticleen_US

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