Protective effect of intravesical platelet-rich plasma on cyclophosphamide-induced hemorrhagic cystitis
Yükleniyor...
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Canadian Soc Clinical Investigation
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: Hemorrhagic cystitis (HC) is the most common urotoxic side effect of cyclophosphamide (CYP). Platelet rich plasma (PRP) plays an important role in wound healing and inflammatory responses. The aim of this study was to investigate the efficacy of intravesical PRP at treatment of interstitial cystitis (IC). Material-Methods: Female rats (n=24) were used. IC was induced by intraperitoneal injection of cyclophosphamide (CYP). Rats were randomly allocated to one of four groups (n = 6 per group): a control group; a sham group with saline (75 mg/kg; i.p.) instead of CYP on day 1; a IC group, which was injected with CYP (150 mg/kg; i.p.) on day 1; and, a intravesical PRP-treated group which was injected with CYP (150 mg/kg; i.p.) on day 1. On day 2, the rats in each group were sacrificed under anesthesia. Results: Histological evaluation showed that bladder inflammation in CYP-treated rats was not suppressed by PRP. CYP administration induced severe IC with marked edema, hemorrhage and inflammation in CYP and CYP+PRP groups, but PRP was not found to be effective to decrease these effects. Conclusion: The application of PRP could not reverse the histopathological changes in rats that had interstitial cystitis due to the cyclophosphamide injection.
Açıklama
Anahtar Kelimeler
[No Keyword]
Kaynak
Clinical and Investigative Medicine
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
39
Sayı
6
Künye
Özyuvalı, E., Yıldırım, M. E., Yaman, T., Kösem, B., Atlı, O. ve Çimentepe, E. (2016). Protective effect of intravesical platelet-rich plasma on cyclophosphamide-induced hemorrhagic cystitis. Clinical and Investigative Medicine, 39(6), 116-120.
