Antioxidant properties of allium turcicum Özhatay & cowley plant extract, its effects on the proliferation and migration of cancer cells

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dc.authorid0000-0003-1756-9757en_US
dc.authorid0000-0002-7230-0489en_US
dc.authorid0000-0003-0274-4479en_US
dc.contributor.authorİpek, Polat
dc.contributor.authorBaran, Ayşe
dc.contributor.authorCebe, Deniz Barış
dc.contributor.authorAhmadian, Elham
dc.contributor.authorEftekhari, Aziz
dc.contributor.authorBaran, Mehmet Fırat
dc.date.accessioned2024-11-06T12:37:48Z
dc.date.available2024-11-06T12:37:48Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Temel Bilimler Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.description.abstractCancer is a type of non-communicable disease that is responsible for numerous deaths worldwide. Cancer incidence and mortality rates are on the rise due to a combination of factors, such as a growing population, aging, and poor dietary habits. The Allium turcicum Özhatay & Cowley plant is an endemic plant in the area where it grows and is consumed by the public due to its various benefits. This endemic plant, which generally grows in high-altitude regions, is sold in bunches because it is costly, mixed with rock salt, crushed into powder, and consumed as a spice. The cytotoxic and growth-inhibitory effects of A. turcicum Özhatay & Cowley herb extract on human glioblastoma U373 cells, human colorectal carcinoma cell HCT-116, and healthy HUVEC cell lines were determined by the MTT method. After 24 and 48 h of application, logIC50 values in HUVEC, HCT-116, and U373 cells were defined as 3.737, 3.765; 3.513, 3.696, 4.476, and 4.104 μg/mL, respectively. We conducted a cell migration experiment to study the A. turcicum Özhatay & Cowley Extract (ATÖCE) impact on cancer cells’ metastatic behavior. Our findings indicate that ATÖCE has an inhibitory effect on the migration potential of the cells used in the study. We conducted experiments using DPPH, ABTS, CUPRAC, and total phenolic content to assess the antioxidant properties of ATÖCE. The findings from the antioxidant activity experiments revealed an activity level of 0.20 ± 0.046 at IC50. Additionally, the total phenolic content was measured to be 0.26 ± 0.044 mg GAE/g. Copyright © 2024 İPEK, Baran, Cebe, Ahmadian, Eftekhari and Baran.en_US
dc.identifier.citationİpek, P., Baran, A., Cebe, D. B., Ahmadian, E., Eftekhari, A. ve Baran, M. F. (2024). Antioxidant properties of allium turcicum Özhatay & cowley plant extract, its effects on the proliferation and migration of cancer cells. Frontiers in Pharmacology, 15, 1-11.en_US
dc.identifier.endpage11en_US
dc.identifier.issn1663-9812
dc.identifier.pmid39372216
dc.identifier.scopus2-s2.0-85205562835
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1438634/full
dc.identifier.urihttps://hdl.handle.net/11468/28918
dc.identifier.volume15en_US
dc.identifier.wosWOS:001335768600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.institutionauthorİpek, Polat
dc.language.isoenen_US
dc.publisherFrontiers Media SAen_US
dc.relation.ispartofFrontiers in Pharmacology
dc.relation.isversionof10.3389/fphar.2024.1438634en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllium turcicum Özhatay & Cowleyen_US
dc.subjectCanceren_US
dc.subjectCell viabilityen_US
dc.subjectCytotoxicityen_US
dc.subjectGlioblastomaen_US
dc.subjectMigrationen_US
dc.titleAntioxidant properties of allium turcicum Özhatay & cowley plant extract, its effects on the proliferation and migration of cancer cellsen_US
dc.titleAntioxidant properties of allium turcicum Özhatay & cowley plant extract, its effects on the proliferation and migration of cancer cells
dc.typeArticleen_US

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