Investigation of the histopathological level of Ki-67, caspase-3 expressions of the effects of hesperidin on wound healing in the rat esophagus

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dc.authorid0000-0002-5797-7926en_US
dc.authorid0000-0003-2497-7011en_US
dc.authorid0000-0002-2353-1184en_US
dc.contributor.authorDurgun, Cemalettin
dc.contributor.authorKirman, Gülşen
dc.contributor.authorDeveci, Engin
dc.date.accessioned2023-10-13T12:57:48Z
dc.date.available2023-10-13T12:57:48Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractPurpose: The effects of hesperidin application on the wound caused by esophageal burns were investigated in this study. Methods: Wistar albino rats were divided into three groups: Control group: only 1 mL of 0.09% NaCl was administered i.p. for 28 days; Burn group: An alkaline esophageal burn model was created with 0.2 mL of 25% NaOH orally by gavage—1 mL of 0.09% NaCl was administered i.p. for 28 days; Burn+Hesperidin group: 1 mL of 50 mL/kg of hesperidin was given i.p. for 28 days to rats after burn injury. Blood samples were collected for biochemical analysis. Esophagus samples were processed for histochemical staining and immunohistochemistry. Results: Malondialdehyde (MDA) and myeloperoxidase (MPO) levels were significantly increased in Burn group. Glutathione (GSH) content and histological scores of epithelialization, collagen formation, neovascularization was decreased. After hesperidin treatment, these values were significantly improved in the Burn+Hesperidin group. In the Burn group, epithelial cells and muscular layers were degenerated. Hesperidin treatment restored these pathologies in Burn+Hesperidin group. Ki-67 and caspase-3 expressions were mainly negative in control group; however, the expression was increased in the Burn group. In the Burn+Hesperidin group, Ki-67 and caspase-3 immune activities were reduced. Conclusion: Hesperidin dosage and application methods can be developed as an alternative treatment for burn healing and treatment.en_US
dc.identifier.citationDurgun, C., Kirman, G. ve Deveci, E. (2023). Investigation of the histopathological level of Ki-67, caspase-3 expressions of the effects of hesperidin on wound healing in the rat esophagus. Acta Cirurgica Brasileira, (38), 1-10.en_US
dc.identifier.doi10.1590/acb381723
dc.identifier.endpage10en_US
dc.identifier.issn0102-8650
dc.identifier.issue38en_US
dc.identifier.pmid37098927
dc.identifier.scopus2-s2.0-85153987254
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.scielo.br/j/acb/a/RnjVrTGBsFQWLmLjR8gRWHL/?lang=en
dc.identifier.urihttps://hdl.handle.net/11468/12810
dc.identifier.wosWOS:000992135500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDeveci, Engin
dc.language.isoenen_US
dc.publisherSociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgiaen_US
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectBurnsen_US
dc.subjectEsophagusen_US
dc.subjectKi-67 antigenen_US
dc.subjectRatsen_US
dc.titleInvestigation of the histopathological level of Ki-67, caspase-3 expressions of the effects of hesperidin on wound healing in the rat esophagusen_US
dc.titleInvestigation of the histopathological level of Ki-67, caspase-3 expressions of the effects of hesperidin on wound healing in the rat esophagus
dc.typeArticleen_US

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