GASTROPROTECTIVE EFFECT OF NITRENDIPINE ON STRESS-INDUCED GASTRIC-LESIONS IN RATS

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dc.contributor.authorULAK, G
dc.contributor.authorCINGI, MI
dc.contributor.authorEROL, K
dc.date.accessioned2024-04-24T17:14:27Z
dc.date.available2024-04-24T17:14:27Z
dc.date.issued1991
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe effects of nitrendipine on stress-induced acute gastric lesions were investigated in rats. Intraperitoneally injected nitrendipine (8, 16, or 32 mg/kg) given 30 min before stress, dose-dependently prevented gastric glandular ulceration. The anti-ulcer effects of nitrendipine were not reversible by indometacin or dexamethasone. These results suggest that calcium is important in gastric pathophysiology and that the proof of gastroprotective effects of calcium channel blockers is of great value in the development of new and improved therapies for treatment and prevention of gastric ulcers in humans.en_US
dc.identifier.doi10.1159/000138848
dc.identifier.endpage224en_US
dc.identifier.issn0031-7012
dc.identifier.issn1423-0313
dc.identifier.issue4en_US
dc.identifier.pmid1771174
dc.identifier.scopus2-s2.0-0025939575
dc.identifier.scopusqualityQ2
dc.identifier.startpage220en_US
dc.identifier.urihttps://doi.org/10.1159/000138848
dc.identifier.urihttps://hdl.handle.net/11468/17954
dc.identifier.volume43en_US
dc.identifier.wosWOS:A1991GT43800005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofPharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCa2+ Channel Blockersen_US
dc.subjectNitrendipineen_US
dc.subjectStress Ulceren_US
dc.subjectIndomethacinen_US
dc.subjectDexamethasoneen_US
dc.titleGASTROPROTECTIVE EFFECT OF NITRENDIPINE ON STRESS-INDUCED GASTRIC-LESIONS IN RATSen_US
dc.titleGASTROPROTECTIVE EFFECT OF NITRENDIPINE ON STRESS-INDUCED GASTRIC-LESIONS IN RATS
dc.typeArticleen_US

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