GASTROPROTECTIVE EFFECT OF NITRENDIPINE ON STRESS-INDUCED GASTRIC-LESIONS IN RATS
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Tarih
1991
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Karger
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The effects of nitrendipine on stress-induced acute gastric lesions were investigated in rats. Intraperitoneally injected nitrendipine (8, 16, or 32 mg/kg) given 30 min before stress, dose-dependently prevented gastric glandular ulceration. The anti-ulcer effects of nitrendipine were not reversible by indometacin or dexamethasone. These results suggest that calcium is important in gastric pathophysiology and that the proof of gastroprotective effects of calcium channel blockers is of great value in the development of new and improved therapies for treatment and prevention of gastric ulcers in humans.
Açıklama
Anahtar Kelimeler
Ca2+ Channel Blockers, Nitrendipine, Stress Ulcer, Indomethacin, Dexamethasone
Kaynak
Pharmacology
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
43
Sayı
4
