β-Hydroxyamide-based ligands and their use in the enantioselective borane reduction of prochiral ketones
Yükleniyor...
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Hydroxyamide-based ligands have occupied a considerable place in asymmetric synthesis. Here we report the synthesis of seven -hydroxyamide-based ligands from the reaction of 2-hydroxynicotinic acid with chiral amino alcohols and test their effect on the enantioselective reduction of aromatic prochiral ketones with borane in tetrahydofuran (THF). They produce the corresponding secondary alcohols with up to 76% enantiomeric excess (ee) and good to excellent yields (86-99%). Chirality 26:21-26, 2013. (c) 2013 Wiley Periodicals, Inc.
Açıklama
Anahtar Kelimeler
Hydroxyamide, Prochiral ketones, Asymmetric borane reduction
Kaynak
Chirality
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
26
Sayı
1
Künye
Azizoğlu, M., Erdoğan, A., Arslan, N. ve Turgut, Y. (2014). β-Hydroxyamide-based ligands and their use in the enantioselective borane reduction of prochiral ketones. Chirality, 26(1), 21-26.
