The contribution of nitric oxide on the relaxation effects of diethylstilbestrol

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dc.contributor.authorHekimoglu, Askin
dc.contributor.authorCelik, Fatma
dc.contributor.authorTas, Taskin
dc.contributor.authorEce, Aydin
dc.contributor.authorKavak, Vatan
dc.date.accessioned2024-04-24T17:38:17Z
dc.date.available2024-04-24T17:38:17Z
dc.date.issued2008
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: To evaluate the contribution of nitric oxide (NO) on the relaxation effects of diethylstilbestrol on rat uterus. Methods: Uterine rings from 8 nonpregnant Wistar Albino rats (300-350g) in the pro-estrous phase were suspended in an organ bath and electrical field stimulation applied for recording isometric tension. The influence of NO on contractile responses of rat uterine rings was investigated. The effects of NO precursor L-arginine (10(-7)-10(-4)M) concentration and NO synthase inhibitor L-nitro-arginine-methyl ester (10(-7)-10(-4)M) concentration and a combination of them on contractile responses were studied in the presence and absence of diethylstilbestrol (2x10(-4)M) concentration. The study was carried out at the Department of Pharmacology Laboratory, Faculty of Medicine, Dicle University, Diyarbakir, Turkey. Results: Totally, 30 samples were investigated (n=6 for each group, 5 groups). Diethylstilbestrol inhibited contractile responses 64.2 +/- 4.5% (n=6, p<0.05). Contractile responses decreased in the presence of Larginine (n=6, p<0.05) and this inhibition was abolished in the presence of L-nitro-arginine-methyl ester (n=6, p<0.05). The inhibition on contractile responses to diethylstilbestrol was potentiated in the presence of Larginine under similar conditions (n=6, p<0.05). The contractile responses to electrical field stimulation in the presence of diethylstilbestrol were not affected by L-nitro-arginine-methyl ester (n=6, p>0.05). Conclusions: These data provide evidence that NO may potentiate the inhibitory effects of diethylstilbestrol by different mechanisms on the electrically induced contractions of the non-pregnant rat uterus.en_US
dc.identifier.endpage667en_US
dc.identifier.issn0379-5284
dc.identifier.issue5en_US
dc.identifier.pmid18454210
dc.identifier.scopus2-s2.0-50949083569
dc.identifier.scopusqualityQ2
dc.identifier.startpage662en_US
dc.identifier.urihttps://hdl.handle.net/11468/21390
dc.identifier.volume29en_US
dc.identifier.wosWOS:000257212100003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSaudi Med Jen_US
dc.relation.ispartofSaudi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleThe contribution of nitric oxide on the relaxation effects of diethylstilbestrolen_US
dc.titleThe contribution of nitric oxide on the relaxation effects of diethylstilbestrol
dc.typeArticleen_US

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