Investigation of Beclin 1 and TNF-? expressions in preeclampsia placentas: Immunohistochemical study

Basit Öğe Kaydı
dc.authorid0000-0002-6384-9146en_US
dc.authorid0000-0002-2353-1184en_US
dc.contributor.authorÖcal, Ece
dc.contributor.authorToprak, Veysel
dc.contributor.authorAkalın, Senem Alkan
dc.contributor.authorAşır, Fırat
dc.contributor.authorDeveci, Engin
dc.date.accessioned2023-11-01T06:10:57Z
dc.date.available2023-11-01T06:10:57Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractBackground: Preeclampsia is a pregnancy complication Aim of this study was to investigate expression of Beclin1 and tumor necrosis factor (TNF)-α in normotensive and preeclamptic placentas of pregnant women patients. Methods: Twenty normotensive and 20 preeclamptic patients placentas were dissected for paraffin- wax processing. Placental samples were embedded in parafin blocks. Sections were stained with Hematoxylin-Eosin staining and TNF-α and Beclin1 immunostaining. Results: In control group, root and floating villi were normal in histological perspectives, syncytial node number was low, vessels were normal with connective tissue. No hemorrhage was observed in the intervillous area. In preeclampsia group, decidual cell degeneration and fibrinoid accumulation increased. Vascular dilatation and congestion with mononuclear cell infiltration were observed. Beclin1 reaction was generally negative in control group. In preeclampsia group, Beclin1 reaction was increased in decidual cells, syncytial nodes and bridges and in chorionic villi and in some Hoffbauer cells. In control group, TNF-α expression was mainly negative but only in some decidual cells. In preeclampsia, TNF-α reaction was observed in degenerated decidua cells, in leukocytes and in villi. Conclusion: In preeclampsia placentas, degenerated decidua cells and inflammation increased. It was thought that Beclin1 and TNF-α signals could be used as a marker in affecting the fetal structure of blood flow in preeclamptic placentas.en_US
dc.identifier.citationÖcal, E., Toprak, V., Akalın, S. A., Aşır, F. ve Deveci, E. (2023). Investigation of Beclin 1 and TNF-α expressions in preeclampsia placentas: Immunohistochemical study. Medicine (United States), 102(33), 1-4.en_US
dc.identifier.doi10.1097/MD.0000000000034757
dc.identifier.endpage4en_US
dc.identifier.issn0025-7974
dc.identifier.issue33en_US
dc.identifier.pmid37603530
dc.identifier.scopus2-s2.0-85168454139
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://journals.lww.com/md-journal/fulltext/2023/08180/investigation_of_beclin_1_and_tnf___expressions_in.32.aspx
dc.identifier.urihttps://hdl.handle.net/11468/13006
dc.identifier.volume102en_US
dc.identifier.wosWOS:001054321500029
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAşır, Fırat
dc.institutionauthorDeveci, Engin
dc.language.isoenen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.relation.ispartofMedicine (United States)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBeclin1en_US
dc.subjectNormotensiveen_US
dc.subjectPlacentaen_US
dc.subjectPreeclampsiaen_US
dc.subjectTNF-αen_US
dc.titleInvestigation of Beclin 1 and TNF-? expressions in preeclampsia placentas: Immunohistochemical studyen_US
dc.titleInvestigation of Beclin 1 and TNF-? expressions in preeclampsia placentas: Immunohistochemical study
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Investigation of Beclin 1 and TNF-α expressions in preeclampsia placentas.pdf
Boyut:
909.76 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Temel Tıp Bilimleri Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu