To what extent does hyaluronic acid affect healing of xenografts? A histomorphometric study in a rabbit model

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dc.authorid101794en_US
dc.authorid122565en_US
dc.authorid131635en_US
dc.authorid121983en_US
dc.authorid0000-0002-1510-8917en_US
dc.authorid0000-0003-1453-5391en_US
dc.authorid0000-0003-2041-6364en_US
dc.authorid0000-0003-1580-9980en_US
dc.authorid0000-0002-2013-9101en_US
dc.contributor.authorArpağ, Osman Fatih
dc.contributor.authorDamlar, İbrahim
dc.contributor.authorAltan, Ahmet
dc.contributor.authorTatlı, Ufuk
dc.contributor.authorGünay, Ahmet
dc.date.accessioned2020-04-07T17:04:50Z
dc.date.available2020-04-07T17:04:50Z
dc.date.issued2018
dc.departmentDicle University, Faculty of Dentistry, Department of Periodontologyen_US
dc.descriptionJournal: Journal of Applied Oral Science (ISSN: 1678-7757, ESSN: 1678-7765) RoMEO: This is a RoMEO ungraded journal Listed in: DOAJ as an open access journal warning - This journal's policies have not been checked by RoMEO. - DOAJ says this is an open access journal, but this may only mean that it is freely available to read. - Most open access journals also permit self-archiving and re-use, but some do not. - Do not assume that self-archiving is allowed, unless it is published under a Creative Commons license. - Please contact the publisher for further information if necessary. - Please contact us if you wish to suggest adding this publisher properly to RoMEO Published by: University of São Pauloen_US
dc.description.abstractAmong the many graft materials that have been used for the treatment of bone defects in oral and maxillofacial regions is xenograft. To improve osteoconductive effects of xenografts, they have been combined with various biocompatible materials, such as hyaluronic acid and bone morphogenetic protein. Objective: To determine bone-healing capacity of high molecular weight hyaluronic acid (HA) combined with xenograft in rabbit calvarial bone defects. Material and methods: Ten adult male New Zealand rabbits (mean weight 3 kg) were included in the study. Three 6-mm-diameter bicortical cranial defects were created on calvarial bone of all rabbits. These defects were filled as follows: a) xenograft; b) HA+xenograft; c) autograft. One month after the first operation, rabbits were sacrificed. Specimens were evaluated histomorphometrically. Results: Considering multiple comparisons, differences regarding new bone were statistically significant between all groups (p<0.05). The volume of residual graft was significantly decreased in HA group compared to xenograft group (p=0.035). Marrow space, trabecular thickness (TbTh), trabecular width (TbWi), trabecular separation (TbSp), and number of node: number of terminus (NNd:NTm) in the autograft group were significantly better than xenograft and HA groups (p<0.05). However, regarding marrow space, TbTh, TbWi, TbSp, and NNd:NTm values, xenograft and HA groups showed similar results and the difference were not significant (p>0.05). Conclusion: These results support that high molecular weight hyaluronic acid could contribute to the healing of xenograft by improving the percentage of new bone formation and reducing the percentage of residual graft. However, HA did not significantly affect the quality of newly formed bone assessed by microarchitectural parameters.en_US
dc.identifier.citationArpağ, O.F., Damlar, İ., Altan, A., Tatlı, U. ve Günay, A. (2018). To what extent does hyaluronic acid affect healing of xenografts? A histomorphometric study in a rabbit model. Journal of Applied Oral Science, 26(18), 1-8.en_US
dc.identifier.doi10.1590/1678-7757-2017-0004
dc.identifier.endpage8en_US
dc.identifier.issn1678-7757
dc.identifier.issn1678-7765
dc.identifier.issue18en_US
dc.identifier.pmid29364337
dc.identifier.scopus2-s2.0-85040987978
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/11468/5219
dc.identifier.urihttp://www.scielo.br/pdf/jaos/v26/1678-7757-jaos-1678-7757-2017-0004.pdf
dc.identifier.volume26en_US
dc.identifier.wosWOS:000423208400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-Belirlenecek
dc.language.isoenen_US
dc.publisherSciEloen_US
dc.relation.ispartofJournal of Applied Oral Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess*
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectHyaluronic aciden_US
dc.subjectXenograften_US
dc.subjectHistological techniqueen_US
dc.subjectBone formationen_US
dc.titleTo what extent does hyaluronic acid affect healing of xenografts? A histomorphometric study in a rabbit modelen_US
dc.titleTo what extent does hyaluronic acid affect healing of xenografts? A histomorphometric study in a rabbit model
dc.typeArticleen_US

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