Serum pregnancy–associated glycoprotein profiles during early gestation in Karya and Konya Merino sheep

dc.authorid0000-0001-7517-4927en_US
dc.authorid0000-0003-0684-7213en_US
dc.authorid0000-0002-0039-5597en_US
dc.authorid0000-0002-4805-0993en_US
dc.authorid0000-0001-5603-2149en_US
dc.authorid0000-0001-6876-2069en_US
dc.authorid0000-0002-3748-9992en_US
dc.authorid0000-0001-7252-7977en_US
dc.contributor.authorAkköse, Mehmet
dc.contributor.authorÇınar, Elif Merve
dc.contributor.authorYazlık, Murat Onur
dc.contributor.authorKaya, Ufuk
dc.contributor.authorPolat, Yadigar
dc.contributor.authorÇebi, Çiğdem
dc.contributor.authorÖzbeyaz, Ceyhan
dc.contributor.authorVural, Mehmet Rıfat
dc.date.accessioned2024-04-04T07:09:10Z
dc.date.available2024-04-04T07:09:10Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Klinik Bilimler Bölümü, Dölerme ve Suni Tohumlama Ana Bilim Dalıen_US
dc.description.abstractBackground: Reported as being expressed by mono- and binucleate placental cells, pregnancy-associated glycoproteins (PAGs) are released into the blood circulation from the ruminant placenta. Circulating gestational PAGs levels may differ between sheep breeds. Objective: This study was aimed at the close monitoring of the serum PAGs profiles of Karya and Konya Merino sheep during early pregnancy. Methods: Fifteen Karya and 15 Konya Merino ewes were synchronized by a 12-day treatment with progesterone-impregnated intravaginal sponges. After the sponges were withdrawn, the ewes were administered 400 IU of equine chorionic gonadotropin. The ewes were allowed to mate naturally, and all animals were sampled for blood as of the day of mating (day 0) at weeks 1, 2, 3, 4 and 5. Pregnancy diagnoses were made by transabdominal ultrasonography at week 5. At weeks 6, 7, 8, 9 and 11, blood samples were collected only from the pregnant ewes. The blood samples were centrifuged at 3000 × g, and extracted sera were stored at −20°C until being used for laboratory analyses. Serum PAGs levels were determined with the aid of a commercial PAG-enzyme-linked immunosorbent assay test originally developed for pregnancy diagnosis in cattle. Differences in the between the PAGs levels throughout pregnancy and the group effect (Karya and Konya Merino) were determined with a two-way mixed analysis of variance. Pairwise comparisons were made using a Bonferroni adjustment. Results: PAGs levels showed a linear increase with the advance of pregnancy in both Karya and Konya Merino sheep. No difference was detected between the breeds for serum PAGs levels. The serum PAGs levels of the pregnant and non-pregnant ewes differed as of the fourth week. Conclusion: The serum PAGs levels of the Karya and Konya Merino ewes were similar during the first 11 weeks of gestation, and pregnancy diagnosis could be made based on serum PAGs levels as of the 4th week in both breeds.en_US
dc.identifier.citationAkköse, M., Çınar, E. M., Yazlık, M. O., Kaya, U., Polat, Y., Çebi, Ç. ve diğerleri. (2024). Serum pregnancy–associated glycoprotein profiles during early gestation in Karya and Konya Merino sheep. Veterinary Medicine and Science, 10(1), 1-7.en_US
dc.identifier.doi10.1002/vms3.1345
dc.identifier.endpage7en_US
dc.identifier.issn2053-1095
dc.identifier.issue1en_US
dc.identifier.pmid38227703
dc.identifier.scopus2-s2.0-85182487777
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/vms3.1345
dc.identifier.urihttps://hdl.handle.net/11468/13832
dc.identifier.volume10en_US
dc.identifier.wosWOS:001142589800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇınar, Elif Merve
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofVeterinary Medicine and Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEween_US
dc.subjectGestationen_US
dc.subjectManagementen_US
dc.subjectPregnancy diagnosisen_US
dc.subjectSerumen_US
dc.titleSerum pregnancy–associated glycoprotein profiles during early gestation in Karya and Konya Merino sheepen_US
dc.titleSerum pregnancy–associated glycoprotein profiles during early gestation in Karya and Konya Merino sheep
dc.typeArticleen_US

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