Serum nitric oxide level could be a predictive biomarker for detection of critical ischaemia duration

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dc.contributor.authorYavuz, Celal
dc.contributor.authorYazici, Suleyman
dc.contributor.authorKarahan, Oguz
dc.contributor.authorDemirtas, Sinan
dc.contributor.authorCaliskan, Ahmet
dc.contributor.authorGuclu, Orkut
dc.contributor.authorErtas, Faruk
dc.date.accessioned2024-04-24T17:20:32Z
dc.date.available2024-04-24T17:20:32Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: To investigate the predictive value of serum nitrate (nitrogen oxide: NOx) levels in the detection of peripheral and mesenteric ischaemia durations. Methods: Rats were sacrificed for determining the basal serum values of NOx in Group I without any intervention. The superior mesenteric artery was clamped in Groups II and III and blood samples were taken at 120 minutes in Group II and at 360 minutes in Group III. The right common femoral artery was clamped in Groups IV and V and blood samples were taken at 120 minutes in Group IV and at 360 minutes in Group V. Results: The peak values of NOx were obtained in Group II and Group IV. NOx levels were reduced in advanced periods of ischaemia. In the other words, the NOx levels were significantly higher at two hours of ischaemia (p<0.05), and NOx levels were reduced to normal ranges at the sixth hour of ischaemia. Conclusion: Early diagnosis and rapid treatment are important for acute ischaemic disorders. Serum NOx levels can be a decisive biomarker for prediction of the critical ischaemia period.en_US
dc.identifier.doi10.3109/1354750X.2012.745165
dc.identifier.endpage120en_US
dc.identifier.issn1354-750X
dc.identifier.issn1366-5804
dc.identifier.issue2en_US
dc.identifier.pmid23312006
dc.identifier.scopus2-s2.0-84873920611
dc.identifier.scopusqualityQ2
dc.identifier.startpage116en_US
dc.identifier.urihttps://doi.org/10.3109/1354750X.2012.745165
dc.identifier.urihttps://hdl.handle.net/11468/19111
dc.identifier.volume18en_US
dc.identifier.wosWOS:000314976000002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiomarkers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Ischaemiaen_US
dc.subjectBiomarkeren_US
dc.subjectIschaemia Durationen_US
dc.subjectNitric Oxideen_US
dc.titleSerum nitric oxide level could be a predictive biomarker for detection of critical ischaemia durationen_US
dc.titleSerum nitric oxide level could be a predictive biomarker for detection of critical ischaemia duration
dc.typeArticleen_US

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