Serum nitric oxide level could be a predictive biomarker for detection of critical ischaemia duration
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Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To investigate the predictive value of serum nitrate (nitrogen oxide: NOx) levels in the detection of peripheral and mesenteric ischaemia durations. Methods: Rats were sacrificed for determining the basal serum values of NOx in Group I without any intervention. The superior mesenteric artery was clamped in Groups II and III and blood samples were taken at 120 minutes in Group II and at 360 minutes in Group III. The right common femoral artery was clamped in Groups IV and V and blood samples were taken at 120 minutes in Group IV and at 360 minutes in Group V. Results: The peak values of NOx were obtained in Group II and Group IV. NOx levels were reduced in advanced periods of ischaemia. In the other words, the NOx levels were significantly higher at two hours of ischaemia (p<0.05), and NOx levels were reduced to normal ranges at the sixth hour of ischaemia. Conclusion: Early diagnosis and rapid treatment are important for acute ischaemic disorders. Serum NOx levels can be a decisive biomarker for prediction of the critical ischaemia period.
Açıklama
Anahtar Kelimeler
Acute Ischaemia, Biomarker, Ischaemia Duration, Nitric Oxide
Kaynak
Biomarkers
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
18
Sayı
2
