The increase in c-fos expression in epileptic seizures is inhibited by magnetic field application, but not KCa1.1 channel expression

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dc.authorid0000-0003-2826-2734en_US
dc.authorid0000-0002-6980-3384en_US
dc.authorid0000-0001-8152-7338en_US
dc.authorid0000-0002-2435-7800en_US
dc.contributor.authorAkdağ, Mehmet Zülkif
dc.contributor.authorOğraş, Emrah
dc.contributor.authorDoğanyiğit, Züleyha
dc.contributor.authorAkyüz, Enes
dc.contributor.authorAkdağ, Mahmut Berat
dc.contributor.authorOkan, Aslı
dc.contributor.authorAkpolat, Veysi
dc.date.accessioned2023-11-01T12:33:47Z
dc.date.available2023-11-01T12:33:47Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalıen_US
dc.description.abstractThe aim of this study was to understand the expression of big potassium (BK, KCa1.1) channels in epileptic seizures under magnetic field application. Forty Wistar albino adult male rats were divided into five groups (n = 8). First group rats were control group. Pentylenetetrazole (PTZ) administrated to second group rats to induce the seizures with 35 mg/kg intraperitoneally injection every two days. Levetiracetam (LEV) i.p. at a dose of 108 mg/kg was given to third group rats as positive control group (PC) before 20 minutes PTZ administration. Pulsed magnetic field with 1.5 mT was exposed to the fourth group rats for 3 hours a day for 1 month as magnetic field (MF) group. 1.5 mT pulsed magnetic field was exposed to the fifth group rats for 3 hours a day for 1 month in addition to PTZ administration (PTZ+MF). KCa1.1 not changed in hippocampus of PTZ rats while increased in frontal cortex and pons for PTZ group but not changed with magnetic field exposure. KCa1.1 increased in heart of PTZ animals and turned back to mean control values with magnetic field exposure. Suppressing the expected increase of c-fos protein expression in seizures with magnetic field application but not being able to change the KCa1.1 expression shows that new studies can be done by increasing the frequency of 1.5 mT magnetic field.en_US
dc.identifier.citationAkdağ, M. Z., Oğraş, E., Doğanyiğit, Z., Akyüz, E., Akdağ, M. B., Okan, A. ve diğerleri. (2023). The increase in c-fos expression in epileptic seizures is inhibited by magnetic field application, but not KCa1.1 channel expression. Electromagnetic Biology and Medicine, 42(2), 81-97.en_US
dc.identifier.doi10.1080/15368378.2023.2247027
dc.identifier.endpage97en_US
dc.identifier.issn1536-8378
dc.identifier.issue2en_US
dc.identifier.pmid37598353
dc.identifier.scopus2-s2.0-85168368040
dc.identifier.scopusqualityQ2
dc.identifier.startpage81en_US
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/15368378.2023.2247027
dc.identifier.urihttps://hdl.handle.net/11468/13017
dc.identifier.volume42en_US
dc.identifier.wosWOS:001050567100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkdağ, Mehmet Zülkif
dc.institutionauthorOğraş, Emrah
dc.institutionauthorAkpolat, Veysi
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofElectromagnetic Biology and Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBK channelsen_US
dc.subjectC-fosen_US
dc.subjectMagnetic fielden_US
dc.subjectPTZ-kindled modelen_US
dc.subjectSeizureen_US
dc.titleThe increase in c-fos expression in epileptic seizures is inhibited by magnetic field application, but not KCa1.1 channel expressionen_US
dc.titleThe increase in c-fos expression in epileptic seizures is inhibited by magnetic field application, but not KCa1.1 channel expression
dc.typeArticleen_US

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