Immunohistochemical distributions of leptin, ghrelin and obestatin hormones in bull and ram abomasum

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dc.authorid0000-0002-0723-4059en_US
dc.authorid0000-0002-8306-491Xen_US
dc.contributor.authorKarakoç, Zelal
dc.contributor.authorTopaloğlu, Uğur
dc.contributor.authorBayram, Bayram
dc.date.accessioned2022-04-18T12:46:35Z
dc.date.available2022-04-18T12:46:35Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Temel Bilimler Bölümü, Laboratuvar Hayvanları Ana Bilim Dalıen_US
dc.descriptionWOS:000768642300001
dc.descriptionPMID: 35288975
dc.description.abstractIn most mammals, leptin plays central and peripheral roles in a wide range of metabolic activities including feed consumption and digestion, energy expenditure and the regulation of carbohydrate-fat accumulation. Ghrelin is a strong appetite-stimulating hormone, while obestatin has the opposite effect of ghrelin. The latter is released during feeding, causing a sense of satiety. This study aimed to reveal if the metabolic hormones, as well as OB-R and GHS-R, were present in bull and ram abomasums. Streptavidin-biotin peroxidase method was implemented to determine the expressions and localizations of metabolic hormones and their receptors, and obestatin. Immunoreactivity for leptin and obestatin was present in the cytoplasms of luminal and glandular cells, while smooth muscle cells were immunoreactant for ghrelin, in both bull and ram abomasums. Immunoreactivity for OB-R was present in luminal and glandular cell, parietal cell cytoplasms, and blood vessels. Immunoreactivity for GHS-R, on the other hand, was found in glandular epithelial cell cytoplasms and parietal cell cytoplasms, in both bull and ram abomasums. Leptin immunoreactivity was detected in the glandular epithelial cells and stroma, and particularly in the parietal cells. Ghrelin immunoreactivity was not observed in glandular epithelial cells. Obestatin immunoreactivity was found intensely in the bull abomasum, while moderate immunoreactivity was observed in the ram abomasums. As such, leptin, ghrelin and obestatin hormones were expressed in bull and ram abomasums, similar to the abomasums of other species. It is believed that these hormones play important roles in the digestive system activities and the regulation of energy in bulls and rams.en_US
dc.identifier.citationKarakoç, Z., Topaloğlu, U. ve Bayram, B. (2022). Immunohistochemical distributions of leptin, ghrelin and obestatin hormones in bull and ram abomasum. Anatomia Histologia Embryologica, 51(3), 411-418.en_US
dc.identifier.issn0340-2096
dc.identifier.issn1439-0264
dc.identifier.issue3
dc.identifier.pmid35288975
dc.identifier.scopusScopusIdYok
dc.identifier.scopusqualityQ2
dc.identifier.startpage411
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1111/ahe.12801
dc.identifier.urihttps://hdl.handle.net/11468/9686
dc.identifier.volume51en_US
dc.identifier.wosWOS:000768642300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKarakoç, Zelal
dc.institutionauthorTopaloğlu, Uğur
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAnatomia Histologia Embryologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectAbomasumen_US
dc.subjectBullen_US
dc.subjectMetabolic hormonesen_US
dc.subjectRamen_US
dc.subjectReceptoren_US
dc.titleImmunohistochemical distributions of leptin, ghrelin and obestatin hormones in bull and ram abomasumen_US
dc.titleImmunohistochemical distributions of leptin, ghrelin and obestatin hormones in bull and ram abomasum
dc.typeArticleen_US

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