The Protective Effects of Caffeic Acid Phenethyl Ester on Acetylsalicylic Acid-induced Lung Injury in Rats

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dc.contributor.authorTaylan, Mahsuk
dc.contributor.authorKaya, Halide
dc.contributor.authorDemir, Melike
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorSen, Hadice Selimoglu
dc.contributor.authorFirat, Ugur
dc.contributor.authorKeles, Aysenur
dc.date.accessioned2024-04-24T17:20:28Z
dc.date.available2024-04-24T17:20:28Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: We aimed to investigate the protective effect of caffeic acid phenethyl ester (CAPE) on acetylsalicylic acid (ASA)-induced lung damage in rats in the present study. Methods: A total of 40 rats were randomly divided into five groups, with eight rats in each groupgroup 1: control, not receiving any medication; group 2: ASA (50mg/kg/day); group 3: ASA (50mg/kg/day) plus CAPE (20g/kg/day); group 4: ASA (100mg/kg/day); and group 5: ASA (100mg/kg/day) plus CAPE (20g/kg/day). ASA and CAPE were given via orogastric gavage for 5days. The total oxidant status (TOS), total antioxidant capacity (TAC), oxidant stress index (OSI), and paraoxonase-1 (PON-1) activity of the blood samples and lung tissues were determined. Histopathological examinations of the lung tissues were performed by using light microscopic methods. Results: CAPE treatment significantly increased antioxidant PON-1 level both in the lung tissue and plasma (p < .05). Plasma antioxidant marker (TAC, PON-1) levels significantly increased and oxidant marker (TOS, OSI) levels significantly decreased in CAPE-treated rats (groups 3,5) compared to ASA given no-CAPE groups (group 2,4) (p < .05). Treatment with CAPE improved pulmonary interstitial inflammation and eosinophil accumulation due to ASA histopathologically. Conclusion: Eosinophil-rich inflammation and oxidative stress play important roles in ASA-induced lung toxicity, and CAPE may protect against ASA-induced lung toxicity by reduction of oxidative damage and inflammation in rats.en_US
dc.identifier.doi10.3109/08941939.2016.1149641
dc.identifier.endpage334en_US
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue6en_US
dc.identifier.pmid26980558
dc.identifier.scopus2-s2.0-84961210529
dc.identifier.scopusqualityQ1
dc.identifier.startpage328en_US
dc.identifier.urihttps://doi.org/10.3109/08941939.2016.1149641
dc.identifier.urihttps://hdl.handle.net/11468/19079
dc.identifier.volume29en_US
dc.identifier.wosWOS:000388745000002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Investigative Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaffeic Acid Phenethyl Esteren_US
dc.subjectCapeen_US
dc.subjectAcetylsalicylic Aciden_US
dc.subjectAsaen_US
dc.subjectLung Injuryen_US
dc.titleThe Protective Effects of Caffeic Acid Phenethyl Ester on Acetylsalicylic Acid-induced Lung Injury in Ratsen_US
dc.titleThe Protective Effects of Caffeic Acid Phenethyl Ester on Acetylsalicylic Acid-induced Lung Injury in Rats
dc.typeArticleen_US

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