The Protective Effects of Caffeic Acid Phenethyl Ester on Acetylsalicylic Acid-induced Lung Injury in Rats
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Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: We aimed to investigate the protective effect of caffeic acid phenethyl ester (CAPE) on acetylsalicylic acid (ASA)-induced lung damage in rats in the present study. Methods: A total of 40 rats were randomly divided into five groups, with eight rats in each groupgroup 1: control, not receiving any medication; group 2: ASA (50mg/kg/day); group 3: ASA (50mg/kg/day) plus CAPE (20g/kg/day); group 4: ASA (100mg/kg/day); and group 5: ASA (100mg/kg/day) plus CAPE (20g/kg/day). ASA and CAPE were given via orogastric gavage for 5days. The total oxidant status (TOS), total antioxidant capacity (TAC), oxidant stress index (OSI), and paraoxonase-1 (PON-1) activity of the blood samples and lung tissues were determined. Histopathological examinations of the lung tissues were performed by using light microscopic methods. Results: CAPE treatment significantly increased antioxidant PON-1 level both in the lung tissue and plasma (p < .05). Plasma antioxidant marker (TAC, PON-1) levels significantly increased and oxidant marker (TOS, OSI) levels significantly decreased in CAPE-treated rats (groups 3,5) compared to ASA given no-CAPE groups (group 2,4) (p < .05). Treatment with CAPE improved pulmonary interstitial inflammation and eosinophil accumulation due to ASA histopathologically. Conclusion: Eosinophil-rich inflammation and oxidative stress play important roles in ASA-induced lung toxicity, and CAPE may protect against ASA-induced lung toxicity by reduction of oxidative damage and inflammation in rats.
Açıklama
Anahtar Kelimeler
Caffeic Acid Phenethyl Ester, Cape, Acetylsalicylic Acid, Asa, Lung Injury
Kaynak
Journal of Investigative Surgery
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
29
Sayı
6
