Effects of toll like receptor 4 (TLR4) and toll like receptor 2 (TLR 2) gene polymorphisms on clinical outcomes in acute non-biliary pancreatitis patients
dc.authorid | 0000-0001-5518-5004 | en_US |
dc.contributor.author | Anılır, Ender | |
dc.contributor.author | Özen, Filiz | |
dc.contributor.author | Yıldırım, İbrahim Halil | |
dc.date.accessioned | 2024-10-17T07:57:26Z | |
dc.date.available | 2024-10-17T07:57:26Z | |
dc.date.issued | 2024 | en_US |
dc.department | Dicle Üniversitesi, Veteriner Fakültesi, Zootekni ve Hayvan Besleme Bölümü, Zootekn Ana Bilim Dalı | en_US |
dc.description.abstract | Introduction: In this retrospective study, it was aimed to evaluate effects of Toll Like Receptor 4 (TLR4) and Toll Like Receptor 2 (TLR 2) gene polymorphisms on clinical outcomes in acute non-biliary pancreatitis patients. Methods: A total of 108 acute non-biliary pancreatitis patients (ANBP) were retrospectively subjected to the study. Gender, age, number of attacks, hospitalization duration, amylase, lipase, aspartate aminotransferase (AST), alanine aminotransferase (ALT), leukocyte, C-reactive protein (CRP), total bilirubin, direct bilirubin, Atlanta score, ultrasonography (USG), Computer Tomography (CT) and patient outcome differences between TLR 4 Rs4986790, TLR 4 Rs4986791 and TLR 2 groups were evaluated. Results: According to TLR 4 Rs4986790 groups, females were significantly common in AA sequence (AA) group with statistically significant difference (p<0.05). Leukocyte mean of AG sequence (AG) group was significantly higher than of AA group (p<0.05). All parameter differences between TLR 4 Rs4986791 and TLR 2 groups were statistically insignificant (p>0.05). there was a statistically significant correlation between TLR 4 Rs4986790 and gender (r=0.265; p<0.01), Leukocyte (r=0.200; p<0.05) and Pseudocyst (r=0.203; p<0.05). TLR 4 Rs4986790 gene polymorphism had significant effect on leukocyte level in acute non-biliary pancreatitis patients (OR: -0.1.900; p<0.05). Predictive value of leukocyte for TLR 4 Rs4986790 was statistically significant (Area Under Curve: 0.624; p<0.05). For 7.65 leukocyte cut off value, sensitivity for AA gene polymorphism was 84.2% and specificity was 40.5% Conclusion: Although the clinical and outcome parameters of ANBP patients in terms of TLR 4 Rs4986791 and TLR 2 do not show significant differences, research findings point to the diagnostic value of patients’ leukocyte parameters in determining TLR-4 Rs4986790 ploimorphism groups. | en_US |
dc.identifier.citation | Anılır, E., Özen, F. ve Yıldırım, İ. H. (2024). Effects of toll like receptor 4 (TLR4) and toll like receptor 2 (TLR 2) gene polymorphisms on clinical outcomes in acute non-biliary pancreatitis patients. Frontiers in Immunology, 15, 1-10. | en_US |
dc.identifier.endpage | 10 | en_US |
dc.identifier.issn | 1664-3224 | |
dc.identifier.pmid | 39221252 | |
dc.identifier.scopus | 2-s2.0-85202676163 | |
dc.identifier.scopusquality | Q1 | |
dc.identifier.startpage | 1 | en_US |
dc.identifier.uri | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1427187/full | |
dc.identifier.uri | https://hdl.handle.net/11468/28858 | |
dc.identifier.volume | 15 | en_US |
dc.identifier.wos | WOS:001301189700001 | |
dc.identifier.wosquality | Q1 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | PubMed | |
dc.indekslendigikaynak | Scopus | |
dc.institutionauthor | Yıldırım, İbrahim Halil | |
dc.language.iso | en | en_US |
dc.publisher | Frontiers Media SA | en_US |
dc.relation.ispartof | Frontiers in Immunology | |
dc.relation.isversionof | 10.3389/fimmu.2024.1427187 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Acute pancreatitis | en_US |
dc.subject | Non-biliary pancreatitis | en_US |
dc.subject | TLR 2 | en_US |
dc.subject | Toll like receptor | en_US |
dc.subject | TRL 4 | en_US |
dc.title | Effects of toll like receptor 4 (TLR4) and toll like receptor 2 (TLR 2) gene polymorphisms on clinical outcomes in acute non-biliary pancreatitis patients | en_US |
dc.title | Effects of toll like receptor 4 (TLR4) and toll like receptor 2 (TLR 2) gene polymorphisms on clinical outcomes in acute non-biliary pancreatitis patients | |
dc.type | Article | en_US |
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