Comparison of topical sucralfate with dexpanthenol in rat wound model

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dc.authorid0000-0002-5648-6498en_US
dc.authorid0000-0001-9843-6301en_US
dc.authorid0000-0002-1659-1189en_US
dc.contributor.authorYıldızhan, Eda
dc.contributor.authorÜlger, Burak Veli
dc.contributor.authorAkkuş, Murat
dc.contributor.authorAkıncı, Dilara
dc.contributor.authorBaşol, Ömer
dc.date.accessioned2023-04-03T08:32:41Z
dc.date.available2023-04-03T08:32:41Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractWound healing is a dynamic process initiated in response to injury. There are many factors that have detrimental effects on the wound healing process. Numerous studies have been conducted for improving wound healing processes. Dexpanthenol is widely used to accelerate wound healing. Sucralfate is used for the treatment of peptic ulcers. We aimed to compare the efficacy of topical Dexpanthenol and Sucralfate in an experimental wound model in rats via histopathological examinations and immune histochemical determinations, as well, to evaluate their effects on EGF levels. Three different groups were formed: the Control Group, the Dexpanthenol Group and the Sucralfate Group. Full-thickness skin wounds were created on the back of each rat and isotonic saline was applied to the wounds of the rats in the control group, Bepanthol(R) cream was applied in Dexpanthenol Group and 10% Sucralfate cream was applied in Sucralfate Group, once a day. On the 7th, 14th and 21st days the wounds were measured and seven rats from each group were sacrificed and the wounds were excised for histopathological examination. Sucralfate increased wound healing rates by increasing neovascularization, fibroblast activation, reepithelialization and collagen density, as well as dexpanthenol. Our study revealed that the dexpanthenol and sucralfate groups were better than the control group in terms of their effects on wound healing, however there was no statistically significant difference among these two groups. Sucralfate improves EGF expression in skin wounds and has positive results on skin wound healing comparable to dexpanthenol.en_US
dc.identifier.citationYıldızhan, E., Ülger, B.V., Akkuş, M., Akıncı, D. ve Başol, Ö. (2022). Comparison of topical sucralfate with dexpanthenol in rat wound model. International Journal of Experimental Pathology, 103(4), 164-170.en_US
dc.identifier.doi10.1111/iep.12441
dc.identifier.endpage170en_US
dc.identifier.issn0959-9673
dc.identifier.issn1365-2613
dc.identifier.issue4en_US
dc.identifier.pmid35441448
dc.identifier.scopus2-s2.0-85128415764
dc.identifier.scopusqualityQ2
dc.identifier.startpage164en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1111/iep.12441
dc.identifier.urihttps://hdl.handle.net/11468/11591
dc.identifier.volume103en_US
dc.identifier.wosWOS:000789531500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYıldızhan, Eda
dc.institutionauthorÜlger, Burak Veli
dc.institutionauthorAkkuş, Murat
dc.institutionauthorAkıncı, Dilara
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Experimental Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDexpanthenolen_US
dc.subjectSucralfateen_US
dc.subjectWound healingen_US
dc.titleComparison of topical sucralfate with dexpanthenol in rat wound modelen_US
dc.titleComparison of topical sucralfate with dexpanthenol in rat wound model
dc.typeArticleen_US

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