Serum TNF-alpha, IL-1 beta, and IL-6 levels in chronic HBV-infected patients

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dc.contributor.authorBekçibaşı, Muhammed
dc.contributor.authorDeveci, Özcan
dc.contributor.authorOğuz, Abdullah
dc.contributor.authorBozkurt, Fatma
dc.contributor.authorDayan, Saim
dc.contributor.authorÇelen, Mustafa Kemal
dc.date.accessioned2022-08-19T11:52:39Z
dc.date.available2022-08-19T11:52:39Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalıen_US
dc.descriptionWOS:000649785600001
dc.descriptionPMID: 33930244
dc.description.abstractBackground The objective of the study was to evaluate the serum levels of tumour necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-6 in chronic HBV-infected patients. Methods The present study was a single centre, prospective and randomised controlled trial. Twenty healthy volunteers and thirty HBeAg-negative patients with planned liver biopsy and treatment-naive diagnosed with chronic hepatitis B (CHB) were included in the study. TNF-alpha, IL-1 beta and IL-6 levels were measured in the serum of CHB patient and control groups using an ELISA. Results were compared statistically using a Mann-Whitney U test. Results The mean age of the CHB group (20 men, 10 women) and the control group (10 men, 10 women) was 33.3 +/- 9.7 (17-55) and 26.1 +/- 12.3 (16-57), respectively. When the two groups were compared with the Mann-Whitney U-test, TNF-alpha and IL-6 levels were found to be significantly higher in the CHB group compared to the control group (P = .003, P < .0001, respectively). Although IL-1 beta levels were not statistically significant, they were higher in the CHB group compared to the controls (P = .07). Conclusions The results of our study showed that serum levels of TNF-alpha and IL-6 are increased in CHB patients.en_US
dc.identifier.citationBekçibaşı, M., Deveci, Ö., Oguz, A., Bozkurt, F., Dayan, S. ve Çelen, M.K. (2021). Serum TNF-alpha, IL-1 beta, and IL-6 levels in chronic HBV-infected patients. International Journal of Clinical Practice, 75(8), 1-4. https://doi.org/10.1111/ijcp.14292en_US
dc.identifier.doi10.1111/ijcp.14292
dc.identifier.endpage4en_US
dc.identifier.issn1742-1241
dc.identifier.issue8en_US
dc.identifier.pmid33930244
dc.identifier.scopus2-s2.0-85105668241
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1111/ijcp.14292
dc.identifier.uri1368-5031
dc.identifier.urihttps://hdl.handle.net/11468/10214
dc.identifier.volume75en_US
dc.identifier.wosWOS:000649785600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOğuz, Abdullah
dc.institutionauthorÇelen, Mustafa Kemal
dc.language.isoenen_US
dc.publisherWiley-Hindawien_US
dc.relation.ispartofInternational Journal of Clinical Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectChronic Hepatitis-Ben_US
dc.titleSerum TNF-alpha, IL-1 beta, and IL-6 levels in chronic HBV-infected patientsen_US
dc.titleSerum TNF-alpha, IL-1 beta, and IL-6 levels in chronic HBV-infected patients
dc.typeArticleen_US

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