Serum TNF-alpha, IL-1 beta, and IL-6 levels in chronic HBV-infected patients
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-Hindawi
Erişim Hakkı
info:eu-repo/semantics/embargoedAccess
Özet
Background The objective of the study was to evaluate the serum levels of tumour necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-6 in chronic HBV-infected patients.
Methods The present study was a single centre, prospective and randomised controlled trial. Twenty healthy volunteers and thirty HBeAg-negative patients with planned liver biopsy and treatment-naive diagnosed with chronic hepatitis B (CHB) were included in the study. TNF-alpha, IL-1 beta and IL-6 levels were measured in the serum of CHB patient and control groups using an ELISA. Results were compared statistically using a Mann-Whitney U test.
Results The mean age of the CHB group (20 men, 10 women) and the control group (10 men, 10 women) was 33.3 +/- 9.7 (17-55) and 26.1 +/- 12.3 (16-57), respectively. When the two groups were compared with the Mann-Whitney U-test, TNF-alpha and IL-6 levels were found to be significantly higher in the CHB group compared to the control group (P = .003, P < .0001, respectively). Although IL-1 beta levels were not statistically significant, they were higher in the CHB group compared to the controls (P = .07).
Conclusions The results of our study showed that serum levels of TNF-alpha and IL-6 are increased in CHB patients.
Açıklama
WOS:000649785600001
PMID: 33930244
PMID: 33930244
Anahtar Kelimeler
Chronic Hepatitis-B
Kaynak
International Journal of Clinical Practice
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
75
Sayı
8
Künye
Bekçibaşı, M., Deveci, Ö., Oguz, A., Bozkurt, F., Dayan, S. ve Çelen, M.K. (2021). Serum TNF-alpha, IL-1 beta, and IL-6 levels in chronic HBV-infected patients. International Journal of Clinical Practice, 75(8), 1-4. https://doi.org/10.1111/ijcp.14292
