The effects of erythropoietin, dextran and saline on brain edema and lipid peroxidation in experimental head trauma

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dc.contributor.authorBasarslan, Seyit Kagan
dc.contributor.authorGocmez, Cuneyt
dc.contributor.authorKamasak, Kagan
dc.contributor.authorEkici, Mehmet Ali
dc.contributor.authorUlutabanca, Halil
dc.contributor.authorDogu, Yurdaer
dc.contributor.authorMenku, Ahmet
dc.date.accessioned2024-04-24T17:27:46Z
dc.date.available2024-04-24T17:27:46Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractBACKGROUND: The aim of this study was to investigate the protective effects of erythropoietin, dextran/saline and erythropoietin in combination with dextran/saline on brain edema and lipid peroxidation following traumatic brain injury in rats. METHODS: In the study, 40 male 3-month-old albino Wistar rats, weighing 250-340 g, were divided into four groups, each consisting of ten rats. Traumatic brain injury was induced in all rats by the weight drop method, and erythropoietin (5,000 U/kg) and/or dextran and saline (8 ml/kg) solutions were injected intraperitoneally ten minutes after trauma. Control animals received an equal volume of serum physiologic. All rats were sacrificed 24 hours later. Glutathione peroxidase activity and malondialdehyde levels were measured in the left hemisphere, and edema was quantitated by the wet dry method. RESULTS: Brain edema and the levels of malondialdehyde, the last product of lipid peroxidation in tissues, were decreased variably, and the activity of glutathione peroxidase, an antioxidant enzyme, was increased in others compared with the control group. CONCLUSION: In this study, it was concluded that the brain edema that developed in rats on which head trauma was induced and the secondary brain damage caused by oxidative stress could be deceased using a combination of erythropoietin, dextran, and saline.en_US
dc.identifier.doi10.5505/tjtes.2015.66502
dc.identifier.endpage240en_US
dc.identifier.issn1306-696X
dc.identifier.issue4en_US
dc.identifier.pmid26374408
dc.identifier.scopus2-s2.0-84936110655
dc.identifier.scopusqualityQ3
dc.identifier.startpage235en_US
dc.identifier.trdizinid197958
dc.identifier.urihttps://doi.org/10.5505/tjtes.2015.66502
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/197958
dc.identifier.urihttps://hdl.handle.net/11468/20186
dc.identifier.volume21en_US
dc.identifier.wosWOS:000359330700001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectBrain Edemaen_US
dc.subjectDextranen_US
dc.subjectErythropoietinen_US
dc.subjectSalineen_US
dc.subjectOxidative Stressen_US
dc.subjectSevere Head Traumaen_US
dc.titleThe effects of erythropoietin, dextran and saline on brain edema and lipid peroxidation in experimental head traumaen_US
dc.titleThe effects of erythropoietin, dextran and saline on brain edema and lipid peroxidation in experimental head trauma
dc.typeArticleen_US

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