Copper and ceruloplasmin levels are closely related to the severity of preeclampsia

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dc.contributor.authorSak, Sibel
dc.contributor.authorBarut, Mert
dc.contributor.authorCelik, Hakim
dc.contributor.authorIncebiyik, Adnan
dc.contributor.authorAgacayak, Elif
dc.contributor.authorUyanikoglu, Hacer
dc.contributor.authorKirmit, Adnan
dc.date.accessioned2024-04-24T17:07:47Z
dc.date.available2024-04-24T17:07:47Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to investigate the maternal serum concentrations of copper (Cu) and ceruloplasmin (CP) in patients with mild preeclampsia, severe preeclampsia, hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome, and to determine their association with the severity of the disease. Methods: This study was carried out at the largest tertiary care health center in the southeast region in Turkey and Department of Obstetrics and Gynecology, Dicle University Hospital. A total of 179 pregnant women, including 58 healthy pregnant women and 71 mild preeclampsia, 26 severe preeclampsia, and 24 HELLP syndrome cases classified according to the American College of Obstetricians and Gynecologists? 2013 guidelines were included in this prospective study. Blood samples were taken from all the pregnant women to evaluate the serum Cu and CP levels. The Cu level was determined via atomic absorption/emission spectroscopy, while the serum CP level was assessed with a nephelometric assay using an automatic image analyzer. Spearman?s rank correlation tests were used to determine the correlations between the serum levels of the antioxidative markers and the preeclampsia severity. Results: The mean???SD of the Cu was 81.2???11.84 ?g/dl in the mild preeclampsia cases and 160.2???20.89 ?g/dl in the severe preeclampsia cases (p?en_US
dc.identifier.doi10.1080/14767058.2018.1487934
dc.identifier.endpage102en_US
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue1en_US
dc.identifier.pmid29886772
dc.identifier.scopus2-s2.0-85050347535
dc.identifier.scopusqualityQ1
dc.identifier.startpage96en_US
dc.identifier.urihttps://doi.org/10.1080/14767058.2018.1487934
dc.identifier.urihttps://hdl.handle.net/11468/16991
dc.identifier.volume33en_US
dc.identifier.wosWOS:000494047100014
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Maternal-Fetal & Neonatal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCeruloplasminen_US
dc.subjectCopperen_US
dc.subjectOxidative Stressen_US
dc.subjectPreeclampsia Severityen_US
dc.titleCopper and ceruloplasmin levels are closely related to the severity of preeclampsiaen_US
dc.titleCopper and ceruloplasmin levels are closely related to the severity of preeclampsia
dc.typeArticleen_US

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