Copper and ceruloplasmin levels are closely related to the severity of preeclampsia
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Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: The aim of this study was to investigate the maternal serum concentrations of copper (Cu) and ceruloplasmin (CP) in patients with mild preeclampsia, severe preeclampsia, hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome, and to determine their association with the severity of the disease. Methods: This study was carried out at the largest tertiary care health center in the southeast region in Turkey and Department of Obstetrics and Gynecology, Dicle University Hospital. A total of 179 pregnant women, including 58 healthy pregnant women and 71 mild preeclampsia, 26 severe preeclampsia, and 24 HELLP syndrome cases classified according to the American College of Obstetricians and Gynecologists? 2013 guidelines were included in this prospective study. Blood samples were taken from all the pregnant women to evaluate the serum Cu and CP levels. The Cu level was determined via atomic absorption/emission spectroscopy, while the serum CP level was assessed with a nephelometric assay using an automatic image analyzer. Spearman?s rank correlation tests were used to determine the correlations between the serum levels of the antioxidative markers and the preeclampsia severity. Results: The mean???SD of the Cu was 81.2???11.84 ?g/dl in the mild preeclampsia cases and 160.2???20.89 ?g/dl in the severe preeclampsia cases (p?
Açıklama
Anahtar Kelimeler
Ceruloplasmin, Copper, Oxidative Stress, Preeclampsia Severity
Kaynak
Journal of Maternal-Fetal & Neonatal Medicine
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
33
Sayı
1
