Efficacy of AdiDetoxTM in reducing the toxicity of fumonisin B1 in rats

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dc.contributor.authorDenli, Muzaffer
dc.contributor.authorBlandon, Juan C.
dc.contributor.authorSalado, Silvia
dc.contributor.authorGuynot, Maria E.
dc.contributor.authorCasas, Josefina
dc.contributor.authorPerez, Jose F.
dc.date.accessioned2024-04-24T16:11:30Z
dc.date.available2024-04-24T16:11:30Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe objective of this study is to evaluate the efficacy of a new mycotoxin inactivator (AdiDetox(TM)) in reducing the toxic effects of fumonisin B-1(FB1) in the diet of rats. Sixty-four male Sprague-Dawley growing rats (125 g +/- 1 g BW) were assigned to eight dietary treatments for seven days. The experiment had a 2 x 4 factorial arrangement with two levels of FB1 (0 mg and 15 mg of FB1,/kg feed) and four levels of AdiDetox(TM) (0 g, 1 g, 2 g and 5 g /kg feed) in the diet No significant differences were observed in the growth performance among treatments (P > 0.05), though low levels of sphingosine (So) and sphinganine (Sa) were detected in the liver. However, So and Sa and the Sa/So ratio in kidneys were higher in rats receiving the FRI diets (P <0.0001) than in those fed the Control diet. Supplementation of AdiDetox(TM) to the diet significantly reduced the toxic effects of FB1, leading to a significant decrease in the Sa content and in the Sa/So ratio in kidneys. In conclusion, the results suggest that AdiDetox(TM) can effectively reduce toxicity of FB1 in growing rats. (C) 2015 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipPROFIT [FIT-0300-2003-335]; CDTI [20050012]; Torres Quevedo [PTQ2004-0869]en_US
dc.description.sponsorshipThis research, part of MONALISA EUREKA Project Sigma 3025!, was supported by PROFIT FIT-0300-2003-335, CDTI 20050012, and Torres Quevedo PTQ2004-0869. We thank Eva Dalmau for her excellent technical assistance with sphingoid bases analysis. This manuscript has been proofread by Mr. Chuck Simmons, a native, English-speaking University Instructor of English.en_US
dc.identifier.doi10.1016/j.fct.2015.01.024
dc.identifier.endpage63en_US
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.pmid25660482
dc.identifier.scopus2-s2.0-84922698216
dc.identifier.scopusqualityQ1
dc.identifier.startpage60en_US
dc.identifier.urihttps://doi.org/10.1016/j.fct.2015.01.024
dc.identifier.urihttps://hdl.handle.net/11468/15414
dc.identifier.volume78en_US
dc.identifier.wosWOS:000352663400008
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofFood and Chemical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFumonisin B-1en_US
dc.subjectAdsorbenten_US
dc.subjectToxicity And Ratsen_US
dc.titleEfficacy of AdiDetoxTM in reducing the toxicity of fumonisin B1 in ratsen_US
dc.titleEfficacy of AdiDetoxTM in reducing the toxicity of fumonisin B1 in rats
dc.typeArticleen_US

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