Efficacy of AdiDetoxTM in reducing the toxicity of fumonisin B1 in rats
dc.contributor.author | Denli, Muzaffer | |
dc.contributor.author | Blandon, Juan C. | |
dc.contributor.author | Salado, Silvia | |
dc.contributor.author | Guynot, Maria E. | |
dc.contributor.author | Casas, Josefina | |
dc.contributor.author | Perez, Jose F. | |
dc.date.accessioned | 2024-04-24T16:11:30Z | |
dc.date.available | 2024-04-24T16:11:30Z | |
dc.date.issued | 2015 | |
dc.department | Dicle Üniversitesi | en_US |
dc.description.abstract | The objective of this study is to evaluate the efficacy of a new mycotoxin inactivator (AdiDetox(TM)) in reducing the toxic effects of fumonisin B-1(FB1) in the diet of rats. Sixty-four male Sprague-Dawley growing rats (125 g +/- 1 g BW) were assigned to eight dietary treatments for seven days. The experiment had a 2 x 4 factorial arrangement with two levels of FB1 (0 mg and 15 mg of FB1,/kg feed) and four levels of AdiDetox(TM) (0 g, 1 g, 2 g and 5 g /kg feed) in the diet No significant differences were observed in the growth performance among treatments (P > 0.05), though low levels of sphingosine (So) and sphinganine (Sa) were detected in the liver. However, So and Sa and the Sa/So ratio in kidneys were higher in rats receiving the FRI diets (P <0.0001) than in those fed the Control diet. Supplementation of AdiDetox(TM) to the diet significantly reduced the toxic effects of FB1, leading to a significant decrease in the Sa content and in the Sa/So ratio in kidneys. In conclusion, the results suggest that AdiDetox(TM) can effectively reduce toxicity of FB1 in growing rats. (C) 2015 Elsevier Ltd. All rights reserved. | en_US |
dc.description.sponsorship | PROFIT [FIT-0300-2003-335]; CDTI [20050012]; Torres Quevedo [PTQ2004-0869] | en_US |
dc.description.sponsorship | This research, part of MONALISA EUREKA Project Sigma 3025!, was supported by PROFIT FIT-0300-2003-335, CDTI 20050012, and Torres Quevedo PTQ2004-0869. We thank Eva Dalmau for her excellent technical assistance with sphingoid bases analysis. This manuscript has been proofread by Mr. Chuck Simmons, a native, English-speaking University Instructor of English. | en_US |
dc.identifier.doi | 10.1016/j.fct.2015.01.024 | |
dc.identifier.endpage | 63 | en_US |
dc.identifier.issn | 0278-6915 | |
dc.identifier.issn | 1873-6351 | |
dc.identifier.pmid | 25660482 | |
dc.identifier.scopus | 2-s2.0-84922698216 | |
dc.identifier.scopusquality | Q1 | |
dc.identifier.startpage | 60 | en_US |
dc.identifier.uri | https://doi.org/10.1016/j.fct.2015.01.024 | |
dc.identifier.uri | https://hdl.handle.net/11468/15414 | |
dc.identifier.volume | 78 | en_US |
dc.identifier.wos | WOS:000352663400008 | |
dc.identifier.wosquality | Q1 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.indekslendigikaynak | PubMed | |
dc.language.iso | en | en_US |
dc.publisher | Pergamon-Elsevier Science Ltd | en_US |
dc.relation.ispartof | Food and Chemical Toxicology | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Fumonisin B-1 | en_US |
dc.subject | Adsorbent | en_US |
dc.subject | Toxicity And Rats | en_US |
dc.title | Efficacy of AdiDetoxTM in reducing the toxicity of fumonisin B1 in rats | en_US |
dc.title | Efficacy of AdiDetoxTM in reducing the toxicity of fumonisin B1 in rats | |
dc.type | Article | en_US |