Efficacy of AdiDetoxTM in reducing the toxicity of fumonisin B1 in rats

The objective of this study is to evaluate the efficacy of a new mycotoxin inactivator (AdiDetox(TM)) in reducing the toxic effects of fumonisin B-1(FB1) in the diet of rats. Sixty-four male Sprague-Dawley growing rats (125 g +/- 1 g BW) were assigned to eight dietary treatments for seven days. The experiment had a 2 x 4 factorial arrangement with two levels of FB1 (0 mg and 15 mg of FB1,/kg feed) and four levels of AdiDetox(TM) (0 g, 1 g, 2 g and 5 g /kg feed) in the diet No significant differences were observed in the growth performance among treatments (P > 0.05), though low levels of sphingosine (So) and sphinganine (Sa) were detected in the liver. However, So and Sa and the Sa/So ratio in kidneys were higher in rats receiving the FRI diets (P <0.0001) than in those fed the Control diet. Supplementation of AdiDetox(TM) to the diet significantly reduced the toxic effects of FB1, leading to a significant decrease in the Sa content and in the Sa/So ratio in kidneys. In conclusion, the results suggest that AdiDetox(TM) can effectively reduce toxicity of FB1 in growing rats. (C) 2015 Elsevier Ltd. All rights reserved.