Effect of Ramadan fasting on platelet aggregation in healthy male subjects

[ X ]

Tarih

1996

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Springer

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

The purpose of this study was to examine platelet aggregation during Ramadan fasting. A group of 20 healthy non-smoking male volunteers were studied, whose mean age was [21 (SD 2.4) years range 19-24]. The average fast was about 15 h. Venous blood samples were taken on 4 different days; 1 day before Ramadan (day 0), then on the 1st, 14th and 28th day of Ramadan, On each of these 4 days, blood samples were taken at 4 p.m. (1 h before the evening meal). Body mass index and platelet count did nor change during fasting. Bleeding and coagulation time had increased significantly by the end of Ramadan fasting (P < 0.05, P < 0.005 respectively), but these changes remained within physiological Limits. Ramadan fasting induced a reduction in platelet sensitivity to adenosine 5'-diphosphate (ADP) and collagen on days 14 (P < 0.05) and 28 (P < 0.05, P < 0.005 respectively). However, adrenaline-induced. platelet aggregation decreased only on day 25 (P < 0.05). This study indicated that Ramadan fasting led to a decrease in the platelet responses of different aggregating agents (ADP, adrenaline and collagen) in vitro. It also led to an increase in bleeding and coagulation time.

Açıklama

Anahtar Kelimeler

Ramadan Fasting, Platelet Aggregation, Blood Lipids, Glucose

Kaynak

European Journal of Applied Physiology

WoS Q Değeri

N/A

Scopus Q Değeri

Q1

Cilt

73

Sayı

6

Künye