Influence of extremely low-frequency magnetic field on chemotherapy and electrochemotherapy efficacy in human Caco-2 colon cancer cells

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dc.authorid0000-0001-6160-5626en_US
dc.authorid0000-0003-2826-2734en_US
dc.contributor.authorAlkış, Mehmet Eşref
dc.contributor.authorAkdağ, Mehmet Zülküf
dc.contributor.authorKandemir, Sevgi İrtegün
dc.date.accessioned2023-03-17T11:39:58Z
dc.date.available2023-03-17T11:39:58Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalıen_US
dc.description.abstractAlthough chemotherapy (CT) has some adverse effects on healthy tissues and cells, it is widely preferred for treating patients with cancer. Drug resistance is one of the major impediments to successful cancer treatment. Electrochemotherapy (ECT) is a technique where cancer cells are rendered permeable to medications. Thanks to this permeability, the dose of the medication required for cancer treatment decreases. Our aim in this study is to examine the effects of short-term extremely low-frequency magnetic fields (ELF-MFs) on CT and ECT treatments in Caco-2 colon cancer cells. The Caco-2 cancer cells were treated with 5-fluorouracil (5-FU, 50 mu M) and ECT (strength:1125 V/cm, duration:100 mu s, frequency:1 Hz), alone as well as in combinations with ELF-MF (4 mT, 10 min). MTT assay was used to determine the efficacy of the treatments. Our findings in the study showed that ECT was much more successful than 5-FU treatment alone in Caco-2 colon cancer cells. Application of 4 mT ELF-MF after CT significantly increased the viability of the Caco-2 cancer cells compared to the CT group alone (p < .05). An increase in the viability of cells treated with 4 mT after ECT was observed compared to ECT alone. Similarly, there was an increase in the viability of cells treated with MF prior to ECT treatment (p < .05). The results show that exposure to ELF-MF at 4 mT flux density significantly reduces CT and ECT treatment efficacy in Caco-2 colon cancer cells.en_US
dc.identifier.citationAlkış, M.E., Akdağ, M.Z. ve Kandemir, S.İ. (2022). Influence of extremely low-frequency magnetic field on chemotherapy and electrochemotherapy efficacy in human Caco-2 colon cancer cells. Electromagnetic Biology and Medicine, 41(2), 177-183.en_US
dc.identifier.doi10.1080/15368378.2022.2046047
dc.identifier.endpage183en_US
dc.identifier.issn1536-8378
dc.identifier.issn1536-8386
dc.identifier.issue2en_US
dc.identifier.pmid35261297
dc.identifier.scopus2-s2.0-85126343591
dc.identifier.scopusqualityQ2
dc.identifier.startpage177en_US
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/15368378.2022.2046047
dc.identifier.urihttps://hdl.handle.net/11468/11444
dc.identifier.volume41en_US
dc.identifier.wosWOS:000766499200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkdağ, Mehmet Zülküf
dc.institutionauthorKandemir, Sevgi İrtegün
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.ispartofElectromagnetic Biology and Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMagnetic fielden_US
dc.subjectCaco-2 cancer cellsen_US
dc.subject5-FUen_US
dc.subjectCytotoxicityen_US
dc.subjectElectrochemotherapyen_US
dc.titleInfluence of extremely low-frequency magnetic field on chemotherapy and electrochemotherapy efficacy in human Caco-2 colon cancer cellsen_US
dc.titleInfluence of extremely low-frequency magnetic field on chemotherapy and electrochemotherapy efficacy in human Caco-2 colon cancer cells
dc.typeArticleen_US

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