Comparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat model

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dc.contributor.authorKaya, Hacer Kayhan
dc.contributor.authorDemirtaş, Berjan
dc.contributor.authorYokuş, Beran
dc.contributor.authorKesim, Dilek Aygün
dc.contributor.authorTaşdemir, Ezel
dc.contributor.authorŞermet, Abdurrahman
dc.date.accessioned2024-04-24T17:20:20Z
dc.date.available2024-04-24T17:20:20Z
dc.date.issued2024
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.description.abstractStatin treatment may increase the risk of diabetes; there is insufficient data on how statins affect glucose regulation and glycemic control and the effects of statins on liver enzymes related to carbohydrate metabolism have not been fully studied. Therefore, we aimed to compare the effects of the statin derivatives, pravastatin, and rosuvastatin, on carbohydrate metabolism in an experimental diabetic rat model. Female Wistar albino rats were used and diabetes was induced by intraperitoneal injection of streptozotocin. Thereafter, 10 and 20 mg kg(-1 )day(-1) doses of both pravastatin and rosuvastatin were administered by oral gavage to the diabetic rats for 8 weeks. At the end of the experiment, body masses, the levels of fasting blood glucose, serum insulin, insulin resistance (HOMA-IR), liver glycogen, and liver enzymes related to carbohydrate metabolism were measured. Both doses of pravastatin significantly in creased the body mass in diabetic rats, however, rosuvastatin, especially at the dose of 20 mg kg(-1 )day(-1) reduced the body mass signi ficantly. Pravastatin, especially at a dose of 20 mg kg(-1 )day(-1), caused significant increases in liver glycogen synthase and glucose 6-phosphate dehydrogenase levels but significant decreases in the levels of glycogen phosphorylase, lactate dehydrogenase, and glucose-6-phosphatase. Hence, pravastatin partially ameliorated the adverse changes in liver enzymes caused by diabetes and, especially at the dose of 20 mg kg(-1 )day(-1), reduced the fasting blood glucose level and increased the liver glycogen content. However, rosuvastatin, especially at the dose of 20 mg kg(-1 )day(-1), significantly reduced the liver glycogen synthase and pyruvate kinase levels, but increased the glycogen phosphorylase level in diabetic rats. Rosuvastatin, 20 mg kg(-1 )day(-1 )dose, caused significant decreases in the body mass and the liver glycogen content of diabetic rats. It can be concluded that pravastatin, especially at the dose of 20 mg kg(-1 )day(-1) is more effective in ameliorating the negative effects of diabetes by modulating carbohydrate metabolism.en_US
dc.description.sponsorshipDicle University Scientific Research Project Coordinator (DUBAP)en_US
dc.description.sponsorshipFinancial support for this study was provided by Dicle University Scientific Research Project Coordinator (DUBAP).en_US
dc.identifier.citationKaya, H. K., Demirtaş, B., Yokuş, B., Kesim, D. A., Taşdemir, E. ve Şermet, A. (2024). Comparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat model. Acta Pharmaceutica, 74(1), 117-130.
dc.identifier.doi10.2478/acph-2024-0001
dc.identifier.endpage130en_US
dc.identifier.issn1330-0075
dc.identifier.issn1846-9558
dc.identifier.issue1en_US
dc.identifier.pmid38554383
dc.identifier.scopus2-s2.0-85189147703
dc.identifier.scopusqualityQ2
dc.identifier.startpage117en_US
dc.identifier.urihttps://doi.org/10.2478/acph-2024-0001
dc.identifier.urihttps://hdl.handle.net/11468/18938
dc.identifier.volume74en_US
dc.identifier.wosWOS:001193872100004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaya, Hacer Kayhan
dc.institutionauthorYokuş, Beran
dc.institutionauthorŞermet, Abdurrahman
dc.language.isoenen_US
dc.publisherSciendoen_US
dc.relation.ispartofActa Pharmaceutica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectPravastatinen_US
dc.subjectRosuvastatinen_US
dc.subjectRaten_US
dc.subjectStreptozotocinen_US
dc.titleComparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat modelen_US
dc.titleComparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat model
dc.typeArticleen_US

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