Phytochemical analysis and biological evaluation of Ferulago setifolia K. Koch

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dc.contributor.authorGözcü, Sefa
dc.contributor.authorAkşit, Zeynep
dc.contributor.authorŞimşek, Samed
dc.contributor.authorKandemir, Ali
dc.contributor.authorAydın, Ali
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorAkşit, Hüseyin
dc.date.accessioned2024-04-24T15:59:27Z
dc.date.available2024-04-24T15:59:27Z
dc.date.issued2023
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractBACKGROUND Ferulago setifolia K. Koch (Apiaceae) has been the subject of this study, aiming to comprehensively determine its phenolic fingerprint and evaluate its various biological activities. The liquid chromatography-tandem mass spectrometry analysis of the 70% methanol extract of F. setifolia (FS) revealed the presence of 23 phytochemicals, among which chlorogenic acid, quinic acid, kaempferol-3-O-glucoside, and quercetin-3-O-glucoside were identified as the major phenolics in the extract.RESULTS The biological screening included examinations of antioxidant, antibacterial, antiproliferative, and cytotoxic activities. The FS extract displayed moderate 2,2-diphenyl-1-picrylhydrazyl radical scavenging and ferric-reducing capacity, indicating moderate antioxidant activity. Furthermore, FS exhibited significant antiproliferative effects on cancer cells while showing low cytotoxicity on normal cells. The antibacterial activity findings revealed that FS demonstrated potent activity against Pseudomonas aeruginosa, Bacillus cereus, Staphylococcus aureus, and Escherichia coli.CONCLUSION The findings of this study suggest that the methanolic extract of FS holds promise as a potential source of biologically active compounds. It can be utilized for the development of pharmaceutical formulations, thanks to its significant antiproliferative and antibacterial activities. Additionally, FS can serve as a valuable source of chlorogenic acid for industrial applications.en_US
dc.description.sponsorshipThis research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.en_US
dc.description.sponsorshipThis research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.en_US
dc.identifier.citationGözcü, S., Akşit, Z., Şimşek, S., Kandemir, A., Aydın, A., Yılmaz, M. A. ve diğerleri. (2024). Phytochemical analysis and biological evaluation of Ferulago setifolia K. Koch. Journal of the Science of Food and Agriculture, 104(3), 1382-1390.
dc.identifier.doi10.1002/jsfa.13017
dc.identifier.issn0022-5142
dc.identifier.issn1097-0010
dc.identifier.pmid37782211
dc.identifier.scopus2-s2.0-85174407527
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/jsfa.13017
dc.identifier.urihttps://hdl.handle.net/11468/14076
dc.identifier.urihttps://scijournals.onlinelibrary.wiley.com/doi/10.1002/jsfa.13017
dc.identifier.wosWOS:001086117200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of The Science of Food and Agriculture
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntiproliferativeen_US
dc.subjectAntioxidanten_US
dc.subjectAntibacterialen_US
dc.subjectLc-Ms/Msen_US
dc.subjectFerulago setifolia K. Kochen_US
dc.titlePhytochemical analysis and biological evaluation of Ferulago setifolia K. Kochen_US
dc.titlePhytochemical analysis and biological evaluation of Ferulago setifolia K. Koch
dc.typeArticleen_US

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