Phytochemical analysis and biological evaluation of Ferulago setifolia K. Koch
Yükleniyor...
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
BACKGROUND Ferulago setifolia K. Koch (Apiaceae) has been the subject of this study, aiming to comprehensively determine its phenolic fingerprint and evaluate its various biological activities. The liquid chromatography-tandem mass spectrometry analysis of the 70% methanol extract of F. setifolia (FS) revealed the presence of 23 phytochemicals, among which chlorogenic acid, quinic acid, kaempferol-3-O-glucoside, and quercetin-3-O-glucoside were identified as the major phenolics in the extract.RESULTS The biological screening included examinations of antioxidant, antibacterial, antiproliferative, and cytotoxic activities. The FS extract displayed moderate 2,2-diphenyl-1-picrylhydrazyl radical scavenging and ferric-reducing capacity, indicating moderate antioxidant activity. Furthermore, FS exhibited significant antiproliferative effects on cancer cells while showing low cytotoxicity on normal cells. The antibacterial activity findings revealed that FS demonstrated potent activity against Pseudomonas aeruginosa, Bacillus cereus, Staphylococcus aureus, and Escherichia coli.CONCLUSION The findings of this study suggest that the methanolic extract of FS holds promise as a potential source of biologically active compounds. It can be utilized for the development of pharmaceutical formulations, thanks to its significant antiproliferative and antibacterial activities. Additionally, FS can serve as a valuable source of chlorogenic acid for industrial applications.
Açıklama
Anahtar Kelimeler
Antiproliferative, Antioxidant, Antibacterial, Lc-Ms/Ms, Ferulago setifolia K. Koch
Kaynak
Journal of The Science of Food and Agriculture
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
Sayı
Künye
Gözcü, S., Akşit, Z., Şimşek, S., Kandemir, A., Aydın, A., Yılmaz, M. A. ve diğerleri. (2024). Phytochemical analysis and biological evaluation of Ferulago setifolia K. Koch. Journal of the Science of Food and Agriculture, 104(3), 1382-1390.
