Protective effects of anise in prevention of cerebral ischemia reperfusion injury in rats

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dc.contributor.authorYıldızhan, Eda
dc.contributor.authorÖzesmer, Hikmet
dc.contributor.authorİnan, Mazlum M.
dc.contributor.authorTatlı, Faruk
dc.contributor.authorRençber, M.
dc.contributor.authorAkbaş, A.
dc.contributor.authorKamar, M.
dc.date.accessioned2023-10-25T13:23:45Z
dc.date.available2023-10-25T13:23:45Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractThe aim of this study is to determine the protective efficacy of anise in cerebral ischemia and reperfusion injury in rats. In this study, 28 Wistar Albino rats, weighing 250-300 grams (g), were used. Four groups were formed with 7 rats in each group. Group 1 (n=7): Control group, Group 2 (n=7): Anise group, 5 mL/kg/day of anise aqueous extract prepared according to Gamberini’s protocol was given orally by gavage for 30 days. Group 3 (n=7): Cerebral ischemia reperfusion (CIR) group, at the beginning of the experiment, 30 minutes of cerebral ischemia and 1 hour of reperfusion were induced and the animals were sacrificed by exanguination. Group 4 (n=7): Anise+ CIR group, After administering 30 days of anise’s aqueous extract, CIR was induced and the study was terminated. TOS values of the Anise+ CIR group was significantly lower than that of the CIR group (p<0.05). Il-6 and TNF-α values of the CIR group were significantly higher than the Anise+ CIR group (p<0,05). Our study revealed that anise ameliorates oxidative damage and inflammation due to cerebral ischemia/reperfusion, by reducing the levels of inflammatory cytokines (TNF-α, Il-6).en_US
dc.identifier.citationYıldızhan, E., Özesmer, H., İnan, M. M., Tatlı, F., Rençber, M., Akbaş, A. ve diğerleri. (2023). Protective effects of anise in prevention of cerebral ischemia reperfusion injury in rats. Polish Journal of Veterinary Sciences, 26(3), 343-347.en_US
dc.identifier.doi10.24425/pjvs.2023.145038
dc.identifier.endpage347en_US
dc.identifier.issn2300-2557
dc.identifier.issue3en_US
dc.identifier.pmid37727035
dc.identifier.scopus2-s2.0-85171900743
dc.identifier.scopusqualityQ3
dc.identifier.startpage343en_US
dc.identifier.urihttps://journals.pan.pl/dlibra/publication/145038/edition/128500/content
dc.identifier.urihttps://hdl.handle.net/11468/12944
dc.identifier.volume26en_US
dc.identifier.wosWOS:001076353600002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYıldızhan, Eda
dc.institutionauthorÖzesmer, Hikmet
dc.institutionauthorİnan, Mazlum M.
dc.institutionauthorAkbaş, A.
dc.institutionauthorKamar, M.
dc.institutionauthorTatlı, Faruk
dc.language.isoenen_US
dc.publisherNLM (Medline)en_US
dc.relation.ispartofPolish Journal of Veterinary Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectAniseen_US
dc.subjectCerebral ischemia reperfusionen_US
dc.subjectOxidative stressen_US
dc.subjectInflammationen_US
dc.titleProtective effects of anise in prevention of cerebral ischemia reperfusion injury in ratsen_US
dc.titleProtective effects of anise in prevention of cerebral ischemia reperfusion injury in rats
dc.typeArticleen_US

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