Investigation of new inflammatory biomarkers in patients with brucella

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dc.authorid0000-0003-2906-8589en_US
dc.authorid0000-0002-2629-783Xen_US
dc.contributor.authorErkan, Revşa Evin Canpolat
dc.contributor.authorTekin, Recep
dc.date.accessioned2024-04-18T12:09:18Z
dc.date.available2024-04-18T12:09:18Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.description.abstractBackground Delayed diagnosis and inadequate treatment of infectious and inflammatory diseases, such as Brucella, lead to high rates of mortality and morbidity. The aim of our study was to investigate the association between serum levels of apelin, presepsin, and irisin with inflammation, laboratory parameters, and blood culture in patients with brucella. Patients and methods This prospective case-control study involves 30 patients with brucellosis and 30 healthy, matched control subjects. Thirty patients who were diagnosed with brucellosis were aged ≥ 18 years. Blood samples were taken from the patients on the first day they were diagnosed with brucellosis. The values of irisin, presepsin, and apelin were studied. In addition, blood samples were also taken from 30 healthy individuals for the control group. Irisin, presepsin, and apelin values that were measured in the patients on the first day were compared with those values measured in the control group. Results The sex and age statuses of the subjects are matched among the groups. The levels of irisin were significantly higher in patients with brucellosis compared to the control group (p<0.045). There was no significant difference between the two groups in terms of apelin and presepsin levels (p values 0.087 and 0.162, respectively). There was a positive correlation between irisin levels and elevated ALT levels, as well as positive blood cultures. Conclusions It appears that the measurement of irisin levels may be beneficial in patients with brucellosis. Irisin can be used as a diagnostic marker for brucella infection and may greatly clinicians to predict the severity disease and treatment response. © 2024 Canpolat Erkan, Tekin. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.description.sponsorshipDicle University Scientific Research Projects Commission TIP.20.037en_US
dc.identifier.citationErkan, R. E. C. ve Tekin, R. (2024). Investigation of new inflammatory biomarkers in patients with brucella. PLoS ONE, 19(2), 1-8.en_US
dc.identifier.doi10.1371/journal.pone.0297550
dc.identifier.endpage8en_US
dc.identifier.issn1932-6203
dc.identifier.issue2en_US
dc.identifier.pmid38359069
dc.identifier.scopus2-s2.0-85185252182
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0297550
dc.identifier.urihttps://hdl.handle.net/11468/13920
dc.identifier.volume19en_US
dc.identifier.wosWOS:001164173200077
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErkan, Revşa Evin Canpolat
dc.institutionauthorTekin, Recep
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPLoS ONE
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiological markeren_US
dc.subjectBrucellaen_US
dc.titleInvestigation of new inflammatory biomarkers in patients with brucellaen_US
dc.titleInvestigation of new inflammatory biomarkers in patients with brucella
dc.typeArticleen_US

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