Short term effects of experimental gastric outlet obstruction and truncal vagotomy on gut hormones

Basit Öğe Kaydı
dc.contributor.authorÖztürk, Aliye Sağkan
dc.contributor.authorAydın, Mehmet
dc.contributor.authorBozkurt, Yeşim Akaydın
dc.contributor.authorKüçükgül, Altuğ
dc.contributor.authorÖztürk, Atakan
dc.date.accessioned2022-06-22T08:49:06Z
dc.date.available2022-06-22T08:49:06Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.descriptionWOS:000629439100001
dc.descriptionPMID: 33722110
dc.description.abstractGastric outlet obstruction (GOO) is caused mainly by pyloric or duodenal blockage; gastric surgery and vagotomy are effective treatments. We investigated the short term effects of experimental GOO and truncal vagotomy (TV) on gut hormone levels. We used 8-week-old male Wistar rats divided randomly into four groups: control, GOO, TV, and GOO + TV. At the end of the experiment, blood and tissue samples of the pylorus and fundus were obtained for biochemical and immunohistochemical analysis. Gastric motility decreased in the TV group, but there was no difference in food intake compared to the control group; water consumption and urine output were increased. Feces excretion and food intake decreased due to loss of food movement from the stomach of GOO and GOO + TV rats. Levels of insulin and ghrelin were lower than for the control group, but levels of cholecystokinin were higher. Leptin and glucagon-like peptide 1 levels were increased in the GOO group, while somatostatin was decreased. Leptin immunostaining levels were decreased in the GOO + TV group. Gastrin and neuropeptide Y levels were lower in the GOO and GOO + TV groups compared to the other groups. We found that both gut hormone levels related to gastric motility and metabolism, and immunohistochemical staining of the stomach tissue were altered by TV and GOO. Measuring changes in gut hormones following gastric surgery could be useful for monitoring the effectiveness of treatmenten_US
dc.identifier.citationÖztürk, A.S., Aydın, M., Bozkurt, Y.A., Küçükgül, A. ve Öztürk, A. (2022). Short term effects of experimental gastric outlet obstruction and truncal vagotomy on gut hormones. Biotechnic & Histochemistry, 97(2), 90-98.en_US
dc.identifier.doi10.1080/10520295.2021.1896780
dc.identifier.endpage98en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue2en_US
dc.identifier.pmid33722110
dc.identifier.scopus2-s2.0-85102726208
dc.identifier.scopusqualityQ2
dc.identifier.startpage90en_US
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/10520295.2021.1896780?scroll=top&needAccess=true
dc.identifier.urihttps://hdl.handle.net/11468/10058
dc.identifier.volume97en_US
dc.identifier.wosWOS:000629439100001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖztürk, Atakan
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCholecystokininen_US
dc.subjectGastric outleten_US
dc.subjectGastrinen_US
dc.subjectGhrelinen_US
dc.subjectGut hormonesen_US
dc.subjectGut motilityen_US
dc.subjectLeptinen_US
dc.subjectMotilinen_US
dc.subjectNeuropeptide Yen_US
dc.subjectObstructionen_US
dc.subjectRatsen_US
dc.subjectSomatostatinen_US
dc.subjectVagotomyen_US
dc.titleShort term effects of experimental gastric outlet obstruction and truncal vagotomy on gut hormonesen_US
dc.titleShort term effects of experimental gastric outlet obstruction and truncal vagotomy on gut hormones
dc.typeArticleen_US

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