Asthma phenotypes in Turkey: a multicenter cross-sectional study in adult asthmatics; PHENOTURK study
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Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background and AimsTo evaluate asthma phenotypes in patients with asthma from different regions of Turkey. MethodsA total of 1400 adult asthmatic patients (mean (SD) age: 44.0 (13.9) years, 75% females) from 14 centers across Turkey were included in this study and a standard questionnaire was applied between the time period of February 2011-January 2012. ResultsThe disease onset40 years of age was higher percentage in obese vs. normal/overweight patients and nonallergic vs. allergic patients (P<0.01). The percentage of patients who had FEV1 values over 80% was higher in allergic than nonallergic and normal/overweight than obese patients (P<0.01). Uncontrolled asthmatics have more severe disease (P<0.01). There were more frequent hospital admissions in nonallergic and uncontrolled asthmatics (P<0.01). Chronic rhino-sinusitis was the leading comorbid disorder in normal/overweight and allergic asthma, while gastroesophageal reflux disorder was more frequent in nonallergic and uncontrolled asthma (P<0.01). Asthma control rate was the highest (39.0%) in patients from Marmara region among all geographical regions (P<0.05). ConclusionIn conclusion, our findings revealed existence of clinical/trigger related phenotypes based on BMI, allergic status, control level and geographical region with more frequent respiratory dysfunction and/or adverse health outcomes in uncontrolled, obese and nonallergic phenotypes.
Açıklama
Anahtar Kelimeler
Allergy-Asthma-Control Level-Disease Onset-Obesity-Phenotypes-Severity
Kaynak
Clinical Respiratory Journal
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
11
Sayı
2
