Anti-Cataract effect of the traditional aqueouse extract of yerba mate (Ilex paraguariensis A. St.-Hil.): An in ovo perspective

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dc.authorid0000-0002-4090-7227en_US
dc.authorid0000-0003-2468-2416en_US
dc.authorid0000-0002-8084-4419en_US
dc.authorid0000-0003-3523-1936en_US
dc.authorid0000-0002-5353-3228en_US
dc.authorid0000-0003-0027-5138en_US
dc.contributor.authorÖncü, Şeyma
dc.contributor.authorKızılkaya, Merve Becit
dc.contributor.authorBilir, Abdulkadir
dc.contributor.authorSarıtaş, Alperen
dc.contributor.authorSöylemez, Evrim Suna Arıkan
dc.contributor.authorKoca, Halit Buğra
dc.contributor.authorFırat, Fatma
dc.contributor.authorKaplan, Afife Büşra Uğur
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.date.accessioned2024-10-17T07:10:53Z
dc.date.available2024-10-17T07:10:53Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractIntroduction: The therapeutic effect of different doses of the traditional aqueous extract of dried leaves of yerba mate (Ilex paraguariensis A. St.-Hil.) was investigated in an experimental cataract model in chicken embryos. Methods and Results: LC-MS/MS analysis allowed the identification and quantification of 53 metabolites. In the hydrocortisone-induced cataract model, lenses were examined morphologically after treatment and parameters related to oxidative stress (total antioxidant/oxidant status (TAS/TOS), glutathione (GSH), and malondialdehyde (MDA)) were evaluated. Antiproliferative cell nuclear antigen (PCNA) and caspase-3 H-scores were determined and crystallin alpha A (CRYAA) gene expression in the lenses was measured by RT-PCR. The degree of cataract decreased in all treatment groups. While there was no significant difference in TAS levels compared to the negative control, TOS, GSH, and MDA levels were dose-dependently regulated. Treatment groups other than the high-dose group regulated the decrease in PCNA and the increase in caspase-3. CRYAA gene expression increased significantly only at the lowest dose. Conclusion: YM, which is becoming increasingly popular as a traditional tea, showed a therapeutic effect on hydrocortisone-induced cataracts in chicken embryos at relatively low doses.en_US
dc.identifier.citationÖncü, Ş., Kızılkaya, M. B., Bilir, A., Sarıtaş, A., Söylemez, E. S. A., Koca, H. B. ve diğerleri. (2024). Anti-Cataract effect of the traditional aqueouse extract of yerba mate (Ilex paraguariensis A. St.-Hil.): An in ovo perspective. Life, 14(8), 1-15.en_US
dc.identifier.endpage15en_US
dc.identifier.issn2075-1729
dc.identifier.issue8en_US
dc.identifier.pmid39202736
dc.identifier.scopus2-s2.0-85202600566
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.mdpi.com/2075-1729/14/8/994
dc.identifier.urihttps://hdl.handle.net/11468/28855
dc.identifier.volume14en_US
dc.identifier.wosWOS:001307280900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.language.isoenen_US
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en_US
dc.relation.ispartofLife
dc.relation.isversionof10.3390/life14080994en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCataracten_US
dc.subjectChick embryoen_US
dc.subjectCRYAAen_US
dc.subjectIlex paraguariensisen_US
dc.subjectYerba mateen_US
dc.titleAnti-Cataract effect of the traditional aqueouse extract of yerba mate (Ilex paraguariensis A. St.-Hil.): An in ovo perspectiveen_US
dc.titleAnti-Cataract effect of the traditional aqueouse extract of yerba mate (Ilex paraguariensis A. St.-Hil.): An in ovo perspective
dc.typeArticleen_US

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