Effects of nicotine administration in rats on MMP2 and VEGF levels in periodontal membrane

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dc.contributor.authorDeveci, Büşra
dc.contributor.authorAyna, Buket Erol
dc.contributor.authorTacir, İbrahim Halil
dc.contributor.authorTuncer, Cudi Mehmet
dc.contributor.authorPala, A.
dc.date.accessioned2022-08-10T08:02:54Z
dc.date.available2022-08-10T08:02:54Z
dc.date.issued2018en_US
dc.departmentDicle Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Bölümüen_US
dc.descriptionPMID: 29345720
dc.description.abstractBackground: Nicotine is associated with increased incidence of periodontal disease and poor response to therapy. This article aimed at identifying the expression of matrix metalloproteinases 2 (MMPs2) and vascular endothelial growth factor (VEGF) proteins on extracellular matrix, fibrous distribution and angiogenetic development in periodontitis caused by nicotine effects on periodontal membrane. Materials and methods: In this experimental study, rats were divided into nicotine and control groups. While the rats in the nicotine group (n = 6) were administered 2 mg/kg nicotine sulphate for 28 days, the animals in the control group (n = 6) were only administered 1.5 mL physiologic saline solution subcutaneously for 28 days. Results: Histological sections were prepared and immunohistochemically stained for MMP2 and VEGF. The sections stained with Trichrome-Masson were observed under light microscope. VEGF and MMP2 immunoreactivity of periodontal gingiva and dentin was assessed by immunohistochemical staining. Conclusions: Nicotine reduces MMP production, disrupts collagen synthesis and causes periodontitis. We observed that nicotine increases periodontitis by disrupting periodontal membrane and prevents tooth to anchor in dental alveoli by disrupting epithelial structure.en_US
dc.identifier.citationDeveci, B., Ayna, B. E., Tacir, İ. H., Tuncer, M. C. ve Pala, A. (2018). Effects of nicotine administration in rats on MMP2 and VEGF levels in periodontal membrane. Folia Morphologica (Poland), 77(3), 471-477.en_US
dc.identifier.doi10.5603/FM.a2018.0004
dc.identifier.endpage477en_US
dc.identifier.issn0015-5659
dc.identifier.issue3en_US
dc.identifier.pmid29345720
dc.identifier.scopus2-s2.0-85053254311
dc.identifier.scopusqualityQ2
dc.identifier.startpage471en_US
dc.identifier.urihttps://journals.viamedica.pl/folia_morphologica/article/view/56553
dc.identifier.urihttps://hdl.handle.net/11468/10165
dc.identifier.volume77en_US
dc.identifier.wosWOS:000444193000009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDeveci, Büşra
dc.institutionauthorAyna, Buket Erol
dc.institutionauthorTacir, İbrahim Halil
dc.institutionauthorTuncer, Mehmet Cudi
dc.institutionauthorPala, A.
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofFolia Morphologica (Poland)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectImmunohistochemistryen_US
dc.subjectMMP2en_US
dc.subjectNicotineen_US
dc.subjectPeriodontal membraneen_US
dc.subjectRaten_US
dc.subjectVEGFen_US
dc.titleEffects of nicotine administration in rats on MMP2 and VEGF levels in periodontal membraneen_US
dc.titleEffects of nicotine administration in rats on MMP2 and VEGF levels in periodontal membrane
dc.typeArticleen_US

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