The role of estrogen receptors, erbB receptors, vascular endothelial growth factor and its receptors, and vascular endothelial growth inhibitor in the development of the rat mammary gland

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dc.contributor.authorSagsoz, Hakan
dc.contributor.authorKetani, Muzaffer Aydin
dc.date.accessioned2024-04-24T17:20:29Z
dc.date.available2024-04-24T17:20:29Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractWe identified the localization and distribution of cell-specific epidermal growth factor receptors (EGFRs erbB-1, erbB-2, erbB-3, erbB-4), vascular endothelial growth factor (VEGF), VEGF receptors [VEGFRs VEGF-R1 (fit-1), VEGF-R2 (flk-1/KDR), VEGF-R3 (fit-4)], vascular endothelial growth inhibitor (VEGI), and estrogen receptor (ER), and determined whether or not these growth factors in rat mammary glands are functional Thirty-five adult female Spraque-Dawley rats were randomly divided Into five groups, each of which were at the 7th, 14th, and 21st day of pregnancy, 7th day post-delivery, and 7th day after weaning It was determined that erbB, VEGF and its receptors, VEGI, and ER stained at different intensities Intense staining was observed, in particular, in erbB receptors during pregnancy and involution, and also in VEGF and its receptors during lactation, while ER stained during the last periods of pregnancy and lactation In conclusion, the expression of erbB, VEGF and its receptors, and ER were determined at varying intensities at different sites of the mammary gland during pregnancy, lactation, and involution periodsen_US
dc.description.sponsorshipScientific Research Council of Dicle University [DU 2008-13-28]en_US
dc.description.sponsorshipThis research was financially supported by the Scientific Research Council of Dicle University (Project No DU 2008-13-28) and has been summarized from the author's doctorate thesis The authors report no conflicts of interest The authors alone are responsible for the content and writing of the paperen_US
dc.identifier.doi10.3109/08977194.2010.495718
dc.identifier.endpage393en_US
dc.identifier.issn0897-7194
dc.identifier.issn1029-2292
dc.identifier.issue6en_US
dc.identifier.pmid20572782
dc.identifier.scopus2-s2.0-78650579935
dc.identifier.scopusqualityQ4
dc.identifier.startpage379en_US
dc.identifier.urihttps://doi.org/10.3109/08977194.2010.495718
dc.identifier.urihttps://hdl.handle.net/11468/19082
dc.identifier.volume28en_US
dc.identifier.wosWOS:000285235200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGrowth Factors
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectErbbsen_US
dc.subjectVegfren_US
dc.subjectVegien_US
dc.subjectMammary Glanden_US
dc.subjectRaten_US
dc.titleThe role of estrogen receptors, erbB receptors, vascular endothelial growth factor and its receptors, and vascular endothelial growth inhibitor in the development of the rat mammary glanden_US
dc.titleThe role of estrogen receptors, erbB receptors, vascular endothelial growth factor and its receptors, and vascular endothelial growth inhibitor in the development of the rat mammary gland
dc.typeArticleen_US

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