The role of estrogen receptors, erbB receptors, vascular endothelial growth factor and its receptors, and vascular endothelial growth inhibitor in the development of the rat mammary gland
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Tarih
2010
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
We identified the localization and distribution of cell-specific epidermal growth factor receptors (EGFRs erbB-1, erbB-2, erbB-3, erbB-4), vascular endothelial growth factor (VEGF), VEGF receptors [VEGFRs VEGF-R1 (fit-1), VEGF-R2 (flk-1/KDR), VEGF-R3 (fit-4)], vascular endothelial growth inhibitor (VEGI), and estrogen receptor (ER), and determined whether or not these growth factors in rat mammary glands are functional Thirty-five adult female Spraque-Dawley rats were randomly divided Into five groups, each of which were at the 7th, 14th, and 21st day of pregnancy, 7th day post-delivery, and 7th day after weaning It was determined that erbB, VEGF and its receptors, VEGI, and ER stained at different intensities Intense staining was observed, in particular, in erbB receptors during pregnancy and involution, and also in VEGF and its receptors during lactation, while ER stained during the last periods of pregnancy and lactation In conclusion, the expression of erbB, VEGF and its receptors, and ER were determined at varying intensities at different sites of the mammary gland during pregnancy, lactation, and involution periods
Açıklama
Anahtar Kelimeler
Erbbs, Vegfr, Vegi, Mammary Gland, Rat
Kaynak
Growth Factors
WoS Q Değeri
Q2
Scopus Q Değeri
Q4
Cilt
28
Sayı
6
