Effects of long-term heat stress and dietary restriction on the expression of genes of steroidogenic pathway and small heat-shock proteins in rat testicular tissue

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dc.authorid0000-0001-9853-5334en_US
dc.authorid0000-0003-4791-8946en_US
dc.authorid0000-0002-9234-1560en_US
dc.authorid0000-0002-0944-2230en_US
dc.authorid0000-0001-9453-4019en_US
dc.contributor.authorBozkaya, Faruk
dc.contributor.authorAtlı, Mehmet Osman
dc.contributor.authorGüzeloǧlu, Aydın
dc.contributor.authorKayış, Seyit Ali
dc.contributor.authorYıldırım, Mehmet Erol
dc.contributor.authorKurar, Ercan
dc.contributor.authorYılmaz, Rahşan
dc.contributor.authorAydilek, Nurettin
dc.date.accessioned2024-03-20T11:49:14Z
dc.date.available2024-03-20T11:49:14Z
dc.date.issued2017en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Klinik Bilimler Bölümü, Dölerme ve Suni Tohumlama Ana Bilim Dalıen_US
dc.description.abstractThe aim was to investigate the effects of long-term heat stress and dietary restriction on the expression of certain genes involving in steroidogenic pathway and small heat-shock proteins (sHSPs) in rat testis. Sprague Dawley rats (n = 24) were equally divided into four groups. Group I and II were kept at an ambient temperature of 22°C, while Groups III and IV were reared at 38°C for 9 weeks. Feed was freely available for Group I and Group III, while Group II and Group IV were fed 60% of the diet consumed by their ad libitum counterparts. At the end of 9 weeks, testicles were collected under euthanasia. Total RNA was isolated from testis tissue samples. Expression profiles of the genes encoding androgen-binding protein, follicle-stimulating hormone receptor, androgen receptor, luteinising hormone receptor, steroidogenic acute regulatory protein (StAR), cyclooxygenase-2 and sHSP genes were assessed at mRNA levels using qPCR. Long-term heat stress decreased the expression of StAR and HspB10 genes while dietary restriction upregulated StAR gene expression. The results suggested that long-term heat stress negatively affected the expression of StAR and HspB10 genes and the dietary restriction was able to reverse negative effect of heat stress on the expression of StAR gene in rat testis.en_US
dc.identifier.citationBozkaya, F., Atlı, M. O., Güzeloğlu, A., Kayış, S. A., Yıldırım, M. A., Kurar, E. ve diğerleri. (2017). Effects of long-term heat stress and dietary restriction on the expression of genes of steroidogenic pathway and small heat-shock proteins in rat testicular tissue. Andrologia, 49(6), 1-7.en_US
dc.identifier.doi10.1111/and.12668
dc.identifier.endpage7en_US
dc.identifier.issn0303-4569
dc.identifier.issue6en_US
dc.identifier.pmid27659778
dc.identifier.scopus2-s2.0-84988908526
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1111/and.12668
dc.identifier.urihttps://hdl.handle.net/11468/13660
dc.identifier.volume49en_US
dc.identifier.wosWOS:000408624600005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAtlı, Mehmet Osman
dc.institutionauthorAydilek, Nurettin
dc.language.isoenen_US
dc.publisherBlackwell Publishing Ltden_US
dc.relation.ispartofAndrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDietary restrictionen_US
dc.subjectHeat stressen_US
dc.subjectsHSPen_US
dc.subjectSteroidogenesisen_US
dc.titleEffects of long-term heat stress and dietary restriction on the expression of genes of steroidogenic pathway and small heat-shock proteins in rat testicular tissueen_US
dc.titleEffects of long-term heat stress and dietary restriction on the expression of genes of steroidogenic pathway and small heat-shock proteins in rat testicular tissue
dc.typeArticleen_US

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