Oxidant/antioxidant status, paraoxonase activity, and lipid profile in plasma of ovariectomized rats under the influence of estrogen, estrogen combined with progesterone, and genistein

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dc.contributor.authorAgacayak, Elif
dc.contributor.authorBasaranoglu, Serdar
dc.contributor.authorTunc, Senem Yaman
dc.contributor.authorIcen, Mehmet Sait
dc.contributor.authorFindik, Fatih Mehmet
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorEvliyaoglu, Osman
dc.date.accessioned2024-04-24T17:18:27Z
dc.date.available2024-04-24T17:18:27Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction: The aim of this study was to investigate whether estradiol (E2), E2 combined with progesterone (Prog) (E2/Prog), and genistein (Gen) treatment had antioxidative and anti-hyperlipidemic effects in the plasma of ovariectomized (OVX) rats. Materials and methods: Adult female Sprague-Dawley rats were divided into five groups. Rats in all groups, except for those in a sham group, underwent bilateral ovariectomy under general anesthesia. The groups were as follows: sham group; control OVX group; group treated with estrogen (0.014 mg/kg 17-beta E2); group treated with a combination of E2 and Prog (0.014 mg/kg 17-beta E2 plus 0.028 mg/kg drospirenone), and group treated with Gen (10 mg/kg/day). Plasma of rats of each treatment group was analyzed to determine the total antioxidant status, total oxidant status, paraoxonase activity, lipid profile, high-density lipoprotein (HDL-chol), low-density lipoprotein (LDL-chol), total cholesterol (Total-C), triacylglycerols, lipoprotein (a), and oxidative stress index. Results: Plasma Total-C levels and body weight increased in all the OVX groups compared with the sham group (P < 0.005). The group treated with E2 had significantly elevated total oxidant status, oxidative stress index, LDL-chol, and Total-C compared with the control group (P < 0.005). Gen treatment might lead to lower LDL-chol and Total-C levels compared with E2 treatment. Conclusions: Gen treatment might be preferred to E2 treatment for treatment of menopausal symptoms in patients at risk for cardiovascular diseases. However, considering the small sample size of this study, larger studies are needed in this area.en_US
dc.identifier.doi10.2147/DDDT.S82263
dc.identifier.endpage2982en_US
dc.identifier.issn1177-8881
dc.identifier.pmid26089646
dc.identifier.scopus2-s2.0-84934918280
dc.identifier.scopusqualityQ1
dc.identifier.startpage2975en_US
dc.identifier.urihttps://doi.org/10.2147/DDDT.S82263
dc.identifier.urihttps://hdl.handle.net/11468/18787
dc.identifier.volume9en_US
dc.identifier.wosWOS:000356191300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofDrug Design Development and Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGenisteinen_US
dc.subjectMenopauseen_US
dc.subjectCardiovascular Diseasesen_US
dc.titleOxidant/antioxidant status, paraoxonase activity, and lipid profile in plasma of ovariectomized rats under the influence of estrogen, estrogen combined with progesterone, and genisteinen_US
dc.titleOxidant/antioxidant status, paraoxonase activity, and lipid profile in plasma of ovariectomized rats under the influence of estrogen, estrogen combined with progesterone, and genistein
dc.typeArticleen_US

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