Central nervous system tuberculosis in children: A review of 214 cases

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dc.authorid0000-0002-5299-9480en_US
dc.authorid0000-0001-8463-2723en_US
dc.authorid0000-0002-0510-965Xen_US
dc.authorid0000-0002-5742-2365en_US
dc.contributor.authorYaramış, Ahmet
dc.contributor.authorGürkan, Fuat
dc.contributor.authorElevli, Murat
dc.contributor.authorSöker, Murat
dc.contributor.authorHaspolat, Yusuf Kenan
dc.contributor.authorKırbaş, Gökhan
dc.contributor.authorTaş, M. Ali
dc.date.accessioned2021-12-09T12:49:06Z
dc.date.available2021-12-09T12:49:06Z
dc.date.issued1998en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractObjective: To study the clinical, laboratory, and treatment features observed in pediatric patients with tuberculous meningitis in Turkey. Study Design. Retrospective case review study. Methods: Review of medical records for demographic data, medical history, clinical manifestations, auxiliary test results, complications, and treatment of 214 children with central nervous system tuberculosis (TB) admitted to Dicle University's hospital between August 1988 and February 1996. Results: Of the 214 patients with tuberculous meningitis, 112 (52%) were male. The mean age at presentation was 4. 1 years, with 165 patients (77%) younger than 5 years. Twenty-two patients (10%) were in the first stage of the disease, 120 (56%) in the second, and 72 (34%) in the third. Our epidemiologic data showed that 141 (66%) of the patients had a family history of TB, and 64 (30%) had a Mantoux skin test result of >10 mm of induration. Radiographic studies demonstrated abnormal chest findings in 187 patients (87%) (hilar adenopathy, 33%; infiltrates, 33%; miliary pattern, 20%; and pleural effusions, 1%, and 172 (80%) cases with hydrocephalus, 26% with parenchymal disease, 15% with basilar meningitis, and 2% with tuberculomas. Only 22 (13%) of 164 children had a positive acid-fast bacilli smear in cerebrospinal fluid, and Mycobacterium tuberculosis was isolated in 49 patients (30%). All the patients were treated with Isoniazid, rifampin, and streptomycin or pyrazinamide for 2 months, followed by 10 months of Isoniazid and rifampin alone. Also, all the patients received adjuvant treatment with steroids early in the course of treatment, and 140 of 172 cases with hydrocephalus had surgical intervention. The overall mortality rate was 23%. Conclusion: One or more of these findings: a family history of TB, positive tuberculin skin test results, abnormal cranial computed tomography, and/or cerebrospinal fluid analysis compatible with TBM were found in all but 3 children in our study.en_US
dc.identifier.citationYaramış, A., Gürkan, F., Elevli, M., Söker, M., Haspolat, Y. K., Kırbaş, G. ve diğerleri. (1998). Central nervous system tuberculosis in children: A review of 214 cases. Pediatrics, 102(5), 1-5.en_US
dc.identifier.doi10.1542/peds.102.5.e49
dc.identifier.endpage5en_US
dc.identifier.issn1073-0397
dc.identifier.issue5en_US
dc.identifier.pmid9794979
dc.identifier.scopus2-s2.0-0032209755
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/11468/8393
dc.identifier.volume102en_US
dc.identifier.wosWOS:000076774600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYaramış, Ahmet
dc.institutionauthorGürkan, Fuat
dc.institutionauthorSöker, Murat
dc.institutionauthorHaspolat, Yusuf Kenan
dc.institutionauthorTaş, M. Ali
dc.language.isoenen_US
dc.publisherAmerican Academy of Pediatricsen_US
dc.relation.ispartofPediatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCentral nervous systemen_US
dc.subjectTuberculous meningitisen_US
dc.subjectDiagnosisen_US
dc.subjectHydrocephalusen_US
dc.subjectChildrenen_US
dc.titleCentral nervous system tuberculosis in children: A review of 214 casesen_US
dc.titleCentral nervous system tuberculosis in children: A review of 214 cases
dc.typeArticleen_US

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