Magnesium sulfate reduces postoperative morphine requirement after remifentanil-based anesthesia

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dc.contributor.authorKaya, Sedat
dc.contributor.authorKararmaz, Alper
dc.contributor.authorGedik, Ruken
dc.contributor.authorTurhanoglu, Selim
dc.date.accessioned2024-04-24T17:37:37Z
dc.date.available2024-04-24T17:37:37Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: The aim was to investigate the effect of magnesium sulfate on postoperative pain and analgesic consumption after remifentanil-based anesthesia. Material/Methods: Forty women 18 to 65 years old were enrolled in this prospective, randomized, double-blinded clinical study. The study solutions were randomly preoperatively prepared for groups M (magnesium) and R (normal saline). A bolus of 0.2 ml/kg of study solution (30 mg/kg magnesium or saline) was given before induction of anesthesia and infusion was started at a rate of 3.3 ml/h (500 mg/h magnesium or saline). A 1 mu g/kg loading close of remifentanil following infusion was started at a rate of 0.25 mu g/kg/min, subsequently increasing stepwise by 0.05 mu g/kg/min increments if insufficient anesthesia was suspected. All postoperative outcome data were collected by all anesthesiologist who was blinded to the anesthetic regimen. Pain intensity using a visual analogue scale (VAS) was recorded for 24 hours postoperatively. Results: Hemodynamic and respiratory variables such as diastolic and systolic blood pressure, heart rate, and oxygen saturation were similar in both groups. The mean intraoperative remifenital consumption in groups M and R was similar. The VAS score was significantly lower in the magnesium group at 15 and 30 minutes postoperatively. Total morphine consumption was significantly lower in the magnesium group than in the remifentanil-alone group. Conclusions: It was concluded that magnesium sulfate decreased the postoperative morphine requirement when remifentanil was used for intraoperative analgesia.en_US
dc.identifier.endpagePI9en_US
dc.identifier.issn1234-1010
dc.identifier.issue2en_US
dc.identifier.pmid19179979en_US
dc.identifier.scopus2-s2.0-66749139013en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpagePI5en_US
dc.identifier.urihttps://hdl.handle.net/11468/21078
dc.identifier.volume15en_US
dc.identifier.wosWOS:000264300800020en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherInt Scientific Literature, Incen_US
dc.relation.ispartofMedical Science Monitoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRemifentanilen_US
dc.subjectMagnesium Sulfateen_US
dc.subjectPostoperative Analgesiaen_US
dc.titleMagnesium sulfate reduces postoperative morphine requirement after remifentanil-based anesthesiaen_US
dc.typeArticleen_US

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