Cypermethrin-induced histopathological and biochemical changes in Nile tilapia (Oreochromis niloticus), and the protective and recuperative effect of ascorbic acid

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dc.contributor.authorKorkmaz, N.
dc.contributor.authorCengiz, E. I.
dc.contributor.authorUnlu, E.
dc.contributor.authorUysal, E.
dc.contributor.authorYanar, M.
dc.date.accessioned2024-04-24T16:11:26Z
dc.date.available2024-04-24T16:11:26Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe objective of this study was to investigate the effects of ascorbic acid on the toxicity of cypermethrin's on histopathological lesions in tissues and protein, glycogen levels in Oreochromis niloticus. Nile tilapia was exposed to 0.22 and 0.44 mu g/l cypermethrin + control diet. 0.22 and 0.44 mu g/l cypermethrin + ascorbic acid supplemented diet for 20 days. The fish were allowed recuperation period of 15 days in pesticide-free water and fed with ascorbic acid suplementation diet. In light microscopic investigation, histopathological lesions were observed in the gill, liver and kidney. The severity of lesions accreted depending on increased pesticide concentration and control diet. Some of the lesions were reversible or at least were less pronounced after recuperation period. Protein levels decreased in some groups after treatment period according to control groups (p < 0.05). The highest depletions in liver, muscle and gill protein levels were found in 0.44 mu g/l cypermethrin + ascorbic acid supplemented diet group (62.23%), in 0.22 mu g/l cypermethrin + control diet group (53.12%) and in 0.44 mu g/l cypermethrin + control diet group (61.87%) after 10 days, respectively. These levels increased at the end of the recuperation period. The highest depletion in liver glycogen levels was found in 0.22 mu g/l cypermethrin + control diet group (50.50%) after 10 days (p < 0.05). At the end of recuperation period, there was no difference between the groups (except 0.22 mu g/l cypermethrin + ascorbic acid supplemented diet group) and controls. The decrease of muscle glycogen, except 0.22 mu g/l cypermethrin + ascorbic acid supplemented diet group, was recorded at the end of 10 and 20 days. In the recuperation period, an increase was observed at all groups. These results revealed that the histopathology, protein and glycogen can work as good indicators of stress of a toxicant on fish. Ascorbic acid serves fish as an antitoxic agent against pesticide toxicity. (C) 2009 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipDicle University [DUAPK-06-FF-42]en_US
dc.description.sponsorshipThis study was financially supported by Dicle University, Research Project Fund (Project no: DUAPK-06-FF-42).en_US
dc.identifier.doi10.1016/j.etap.2009.04.004
dc.identifier.endpage205en_US
dc.identifier.issn1382-6689
dc.identifier.issn1872-7077
dc.identifier.issue2en_US
dc.identifier.pmid21784003
dc.identifier.scopus2-s2.0-67650241912
dc.identifier.scopusqualityQ1
dc.identifier.startpage198en_US
dc.identifier.urihttps://doi.org/10.1016/j.etap.2009.04.004
dc.identifier.urihttps://hdl.handle.net/11468/15390
dc.identifier.volume28en_US
dc.identifier.wosWOS:000268791800007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofEnvironmental Toxicology and Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAscorbic Aciden_US
dc.subjectAlpha Cypermethrinen_US
dc.subjectNile Tilapiaen_US
dc.subjectOreochromis Niloticusen_US
dc.subjectHistopathological Lesions, Biochemical Parametersen_US
dc.titleCypermethrin-induced histopathological and biochemical changes in Nile tilapia (Oreochromis niloticus), and the protective and recuperative effect of ascorbic aciden_US
dc.titleCypermethrin-induced histopathological and biochemical changes in Nile tilapia (Oreochromis niloticus), and the protective and recuperative effect of ascorbic acid
dc.typeArticleen_US

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