Evaluation of iron overload in visceral organs in thalassemia patients by point shear-wave elastography

Basit Öğe Kaydı
dc.contributor.authorHattapoglu, Salih
dc.contributor.authorCetincakmak, Mehmet Guli
dc.date.accessioned2025-02-22T14:09:04Z
dc.date.available2025-02-22T14:09:04Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction The aim of this study was to investigate the value of point shear-wave elastography (pSWE) in the measurement of iron overload in the liver and other visceral organs in patients with beta thalassemia major (BTM). Materials and methods The study included 103 patients diagnosed with BTM who were referred to our clinic for cardiac and liver T2* measurement and a control group of 120 age- and gender-matched healthy volunteers. Cardiac and hepatic T2* measurements were performed in the patient group. Hepatic, pancreatic, splenic, and renal pSWE values were measured in both groups. The pSWE values were compared between the two groups. In the patient group, correlations between pSWE values, cardiac-hepatic T2* values and hepatic size, patient age, and serum ferritin levels were analyzed. Results Hepatic, pancreatic, splenic, and renal pSWE values were significantly higher in the patient group compared to the control group (p <= 0.001, < 0.001, 0.014, 0.026, respectively). In the patient group, hepatic pSWE values established a significant correlation with cardiac T2* values, liver size-T2*, pancreatic pSWE values, serum ferritin levels, and age (p = 0.006, < 0.001, 0.001, 0.042, 0.001, 0.032, respectively). In the ROC analysis, the area under the ROC curve was 0.807 for hepatic pSWE in the discrimination of thalassemia patients and healthy controls, and the cut-off value was 1.42, which gave a sensitivity and specificity of 75.7% and 75%, respectively. Conclus & imath;on Point shear-wave elastography can be a useful technique in the clinical measurement of iron overload in the liver, pancreas, spleen, and kidney.en_US
dc.identifier.doi10.1007/s11845-024-03719-0
dc.identifier.endpage2412en_US
dc.identifier.issn0021-1265
dc.identifier.issn1863-4362
dc.identifier.issue5en_US
dc.identifier.pmid38789665en_US
dc.identifier.scopus2-s2.0-85193935543en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2407en_US
dc.identifier.urihttps://doi.org/10.1007/s11845-024-03719-0
dc.identifier.urihttps://hdl.handle.net/11468/29783
dc.identifier.volume193en_US
dc.identifier.wosWOS:001234588300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofIrish Journal of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectBeta thalassemia majoren_US
dc.subjectIron overloaden_US
dc.subjectLiveren_US
dc.subjectPoint shear-wave elastographyen_US
dc.titleEvaluation of iron overload in visceral organs in thalassemia patients by point shear-wave elastographyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu