The effect of dietary supplementation of Nigella sativa L. on serum lipid profile in rats
| dc.contributor.author | Kocyigit, Yuksel | |
| dc.contributor.author | Atamer, Yildiz | |
| dc.contributor.author | Uysal, Ersin | |
| dc.date.accessioned | 2024-04-24T17:38:18Z | |
| dc.date.available | 2024-04-24T17:38:18Z | |
| dc.date.issued | 2009 | |
| dc.department | Dicle Üniversitesi | en_US |
| dc.description.abstract | Objectives: To investigate the effect of oral treatment of Wistar albino rats with different doses of Nigella sativa L. (NS) powdered seeds on the levels of serum lipids. Methods: This study was performed in the Medical Science Application and Research Center of Dicle University, Diyarbakir, Turkey, from February 2003 to December 2008. A total of 75 Wistar albino male rats, 60 of them with NS supplementation and 15 animals acting as controls, were included in the study. The NS groups were divided into 4 main groups of 15 each. Four doses of NS were used (100, 200, 400, and 600mg/kg/day). Each dose group was further divided into 3 duration subgroups of 5 rats each, the feeding of NS seeds continued for one, 2, and 4 weeks. Control animals were divided into 3 main groups of 5 rats each. The rats were sacrificed at one, 2, and 4 weeks after feeding. Lipid parameters were measured. Results: Rats treated with the 400mg dose for one week's duration showed a significant increase in high-density lipoprotein-cholesterol levels. There was a significant decrease in low density lipoprotein-cholesterol levels after one week for 400 and 600mg doses, and all doses after 2 weeks and 4 weeks for 200 and 600mg doses when compared to control groups. There was a significant decrease in very low-density lipoprotein-cholesterol levels after one week for 200, 400, and 600mg doses, and all doses for 2 and 4 weeks. A 400mg dose for 2 weeks, and all doses for 4 weeks caused a significant decrease in triglyceride levels. There was a significant decrease of total cholesterol levels in all doses after 4 weeks of NS feeding. Conclusion: These results indicate that NS may a-meliorate the alteration in the lipid levels caused by diseases or toxic agents. | en_US |
| dc.identifier.endpage | 896 | en_US |
| dc.identifier.issn | 0379-5284 | |
| dc.identifier.issue | 7 | en_US |
| dc.identifier.pmid | 19618002 | |
| dc.identifier.scopus | 2-s2.0-70349503806 | |
| dc.identifier.scopusquality | Q2 | |
| dc.identifier.startpage | 893 | en_US |
| dc.identifier.uri | https://hdl.handle.net/11468/21400 | |
| dc.identifier.volume | 30 | en_US |
| dc.identifier.wos | WOS:000269388100006 | |
| dc.identifier.wosquality | Q4 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | en_US |
| dc.publisher | Saudi Med J | en_US |
| dc.relation.ispartof | Saudi Medical Journal | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | [No Keyword] | en_US |
| dc.title | The effect of dietary supplementation of Nigella sativa L. on serum lipid profile in rats | en_US |
| dc.title | The effect of dietary supplementation of Nigella sativa L. on serum lipid profile in rats | |
| dc.type | Article | en_US |
