Risk factors for enteric perforation in patients with typhoid fever

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dc.contributor.authorHosoglu, S
dc.contributor.authorAldemir, M
dc.contributor.authorAkalin, S
dc.contributor.authorGeyik, MF
dc.contributor.authorTacyildiz, IH
dc.contributor.authorLoeb, M
dc.date.accessioned2024-04-24T17:08:03Z
dc.date.available2024-04-24T17:08:03Z
dc.date.issued2004
dc.departmentDicle Üniversitesien_US
dc.description.abstractA case-control study was performed using the records of patients hospitalized for typhoid fever at Dicle University Hospital, Diyarbakir, Turkey, between 1994 and 1998. Case patients with enteric perforation were compared with control patients with typhoid fever but no enteric perforation. Risk factors for perforation were determined using logistic regression modeling. Forty case patients who had surgery because of typhoid enteric perforation were compared with 80 control patients. In univariate analyses, male sex (p = 0.01), age (p = 0.01), leukopenia (p = 0.01), inadequate antimicrobial therapy prior to admission (p = 0.01), and short duration of symptoms (p = 0.01) were significantly associated with perforation. In multivariate analysis, male sex (odds ratio (OR) = 4.39, 95% confidence interval (CI): 1.37, 14.09; p = 0.01), leukopenia (OR = 3.88, 95% CI: 1.46, 10.33; p = 0.04), inadequate treatment prior to admission (OR = 4.58, 95% CI: 1.14, 18.35; p = 0.03), and short duration of symptoms (OR = 1.22, 95% CI: 1.10, 1.35; p = 0.001) were significant predictors of perforation. A short duration of symptoms, inadequate antimicrobial therapy, male sex, and leukopenia are independent risk factors for enteric perforation in patients with typhoid fever.en_US
dc.identifier.doi10.1093/aje/kwh172
dc.identifier.endpage50en_US
dc.identifier.issn0002-9262
dc.identifier.issn1476-6256
dc.identifier.issue1en_US
dc.identifier.pmid15229116
dc.identifier.scopus2-s2.0-3042719922
dc.identifier.scopusqualityQ1
dc.identifier.startpage46en_US
dc.identifier.urihttps://doi.org/10.1093/aje/kwh172
dc.identifier.urihttps://hdl.handle.net/11468/17179
dc.identifier.volume160en_US
dc.identifier.wosWOS:000222403100007
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherOxford Univ Press Incen_US
dc.relation.ispartofAmerican Journal of Epidemiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntestinal Perforationen_US
dc.subjectMultivariate Analysisen_US
dc.subjectRisk Factorsen_US
dc.subjectTyphoid Feveren_US
dc.titleRisk factors for enteric perforation in patients with typhoid feveren_US
dc.titleRisk factors for enteric perforation in patients with typhoid fever
dc.typeArticleen_US

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