Thiol-disulphide homeostasis and ischemia-modified albumin level and its relationship with clinicopathological features of breast cancer

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dc.authorid0000-0002-7931-2941en_US
dc.authorid0000-0002-7451-2786en_US
dc.contributor.authorHunur, Uğur
dc.contributor.authorOruç, Zeynep
dc.contributor.authorEbinç, Senar
dc.contributor.authorOruç, İdris
dc.contributor.authorNeşelioǧlu, Salim
dc.contributor.authorIşıkdoğan, Abdurrahman
dc.date.accessioned2024-01-24T11:38:02Z
dc.date.available2024-01-24T11:38:02Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractObjective: To investigate the status of thiol-disulphide homeostasis and ischemic-modified albumin and their association with clinicopathological parameters in breast cancer. Study Design: A cross-sectional descriptive study. Place and Duration of Study: Department of Internal Medicine and Department of Medical Oncology, Dicle University, Turkey, from April to September 2021. Methodology: Forty treatment-naive female patients diagnosed with breast cancer who presented to the Oncology Clinic of the hospital and 33 healthy women with no comorbidities were included. Serum levels of native thiol (NT), disulphide (Ds), total thiol (TT), IMA (ischemic modified albumin) at diagnosis and disulphide/native thiol (Ds/NT), disulphide/total thiol (Ds/TT), and the ratios of native thiol/total thiol (NT/TT) were analysed by the colorimetric method. Results: Median age at diagnosis was 44 (29-70) years. The majority of patients had stage II-III disease (77.5%). Mean serum levels of TT were significantly lower in breast cancer patients (462.45 100.2 umol/L) compared to healthy controls (507.28 75.72 umol/L) (p=0.038). Mean serum levels of Ds were significantly lower in breast cancer patients (20.25 5.94 umol/L) compared to healthy controls (22.99 3.56 umol/L) (p=0.018). Meanwhile, mean IMA levels were significantly higher in breast cancer patients (0.81 0.05 umol/L) compared to healthy controls (0.73 0.19 umol/L) (p=0.016). NT and TT levels showed a moderate correlation with the percentage of fat mass and body mass index (BMI), and a weak correlation with age (p0.05). Univariate and multivariate analyses examining the association between thiol-disulphide levels and patient clinical characteristics demonstrated that NT and TT levels had a statistically significant relationship with body mass index and menopausal status (p0.05), with lower levels of NT and TT in postmenopausal patients and patients with high BMI. Conclusion: Decreased TT and Ds levels and increased IMA levels were determined in patients diagnosed with breast cancer compared to the healthy control group. Thiol-disulphide levels were observed to be associated with clinical characteristics such as menopausal status and BMI.en_US
dc.identifier.citationHunur, U., Oruç, Z., Ebinç, S., Oruç, İ., Neşelioğlu, S. ve Işıkdoğan, A. (2022). Thiol-disulphide homeostasis and ischemia-modified albumin level and its relationship with clinicopathological features of breast cancer. Journal of the College of Physicians and Surgeons Pakistan, 32(11), 1435-1440.en_US
dc.identifier.doi10.29271/jcpsp.2022.11.1435
dc.identifier.endpage1440en_US
dc.identifier.issn1022-386X
dc.identifier.issue11en_US
dc.identifier.pmid36377011
dc.identifier.scopus2-s2.0-85141258049
dc.identifier.scopusqualityQ2
dc.identifier.startpage1435en_US
dc.identifier.urihttps://jcpsp.pk/article-detail/pthioldisulphide-homeostas%C4%B1s-and-ischemiamodified-album%C4%B1n-level-and-its-relat%C4%B1onsh%C4%B1p-with-cl%C4%B1nicopathological-features-of-breast-cancerorp
dc.identifier.urihttps://hdl.handle.net/11468/13267
dc.identifier.volume32en_US
dc.identifier.wosWOS:000921592400012
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorHunur, Uğur
dc.institutionauthorOruç, Zeynep
dc.institutionauthorEbinç, Senar
dc.institutionauthorOruç, İdris
dc.institutionauthorIşıkdoğan, Abdurrahman
dc.language.isoenen_US
dc.publisherCollege of Physicians and Surgeons Pakistanen_US
dc.relation.ispartofJournal of the College of Physicians and Surgeons Pakistan
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectBreast canceren_US
dc.subjectIschemic modified albuminen_US
dc.subjectThiolen_US
dc.titleThiol-disulphide homeostasis and ischemia-modified albumin level and its relationship with clinicopathological features of breast canceren_US
dc.titleThiol-disulphide homeostasis and ischemia-modified albumin level and its relationship with clinicopathological features of breast cancer
dc.typeArticleen_US

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