Expression of p53 oncoprotein and bcl-2 in renal cell carcinoma

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dc.contributor.authorUzunlar, AK
dc.contributor.authorSahin, H
dc.contributor.authorYilmaz, F
dc.contributor.authorOzekinci, S
dc.date.accessioned2024-04-24T17:33:56Z
dc.date.available2024-04-24T17:33:56Z
dc.date.issued2005
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The aim of the present study was to investigate the significance of p53 and bcl-2 as prognostic factors among others in renal cell carcinoma patients. Methods: We evaluated the stages, histological grades, tumor diameters, cellular patterns and the presence of mutant p53 protein and bcl-2 overexpression in 57 cases of renal cell carcinoma (RCC). Kaplan-Meier and log-rank tests estimated the survival function of each parameter. The study was carried out in the Department of Pathology and the Department of Urology, Faculty of Medicine, Dicle University Hospital, Diyarbakir, Turkey, in 2003. Results: The p53 mutation was 35% and bcl-2 overexpression incidence was 89.4% in the RCC cases included in the study. The 5-year disease specific survival rates of mutant p53 positive was 46.6% and p53 negative cases were 83.3%, (p=0.0063). There was no pathological parameter associated in bcl-2, and it has no prognostic significance. Conclusion: The tumor stage, grade, diameter and p53 mutations affect the survival of RCC cases. The bcl-2 staining did not play any role to estimate patients at high risk of the disease progression.en_US
dc.identifier.endpage41en_US
dc.identifier.issn0379-5284
dc.identifier.issue1en_US
dc.identifier.pmid15756350
dc.identifier.scopus2-s2.0-14944365551
dc.identifier.scopusqualityQ2
dc.identifier.startpage37en_US
dc.identifier.urihttps://hdl.handle.net/11468/20893
dc.identifier.volume26en_US
dc.identifier.wosWOS:000227587800006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSaudi Med Jen_US
dc.relation.ispartofSaudi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleExpression of p53 oncoprotein and bcl-2 in renal cell carcinomaen_US
dc.titleExpression of p53 oncoprotein and bcl-2 in renal cell carcinoma
dc.typeArticleen_US

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